Rivaroxaban and Warfarin Interaction
Drug interaction information between Rivaroxaban and Warfarin.
Rivaroxaban and Warfarin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Rivaroxaban and Warfarin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These are both powerful blood thinners, and using them together significantly raises the chance of dangerous bleeding.
FDA Label Information
7.4 Anticoagulants and NSAIDs/Aspirin Coadministration of enoxaparin, warfarin, aspirin, clopidogrel and chronic NSAID use may increase the risk of bleeding [see Clinical Pharmacology (12.3) ].
Rivaroxaban Also Interacts With
- Clopidogrel moderate
- Aspirin moderate
- Ketoconazole moderate
- Carbamazepine moderate
- Erythromycin moderate
Warfarin Also Interacts With
- Fluoxetine major
- Tamoxifen major
- Ibuprofen moderate
- Aspirin moderate
- Diclofenac moderate
Frequently Asked Questions
What SPL severity band is on file for Rivaroxaban + Warfarin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Warfarin has 163 labeled pairs on file vs Rivaroxaban's 14. In the moderate band specifically: Rivaroxaban has 13 (also Clopidogrel, Aspirin, Ketoconazole, Carbamazepine); Warfarin has 28 (also Ibuprofen, Aspirin, Diclofenac, Desvenlafaxine).
What mechanism field is on file for Rivaroxaban and Warfarin?
These are both powerful blood thinners, and using them together significantly raises the chance of dangerous bleeding.
Warfarin carries more major-labeled pairs than Rivaroxaban
SPL source-record counts only. This page's band is moderate · classes on file: Rivaroxaban (Direct Oral Anticoagulant (Factor Xa Inhibitor)); Warfarin (Vitamin K Antagonist (Anticoagulant)).
Warfarin has 2 major-labeled pairs vs Rivaroxaban's 0. This page itself is in the moderate band, not the major band.
0 major · 13 moderate · 1 minor · 14 total
- Other moderate peers for Rivaroxaban
- Clopidogrel
- Aspirin
- Ketoconazole
- Carbamazepine
2 major · 28 moderate · 133 minor · 163 total
- Other moderate peers for Warfarin
- Ibuprofen
- Aspirin
- Diclofenac
- Desvenlafaxine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.