Tranylcypromine and Acetaminophen/Oxycodone Interaction
Drug interaction information between Tranylcypromine and Acetaminophen/Oxycodone.
Tranylcypromine and Acetaminophen/Oxycodone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Tranylcypromine and Acetaminophen/Oxycodone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This combination can cause serious side effects like extreme sleepiness, breathing trouble, or a dangerous reaction in the brain. It happens because the two drugs interfere with each other's effects on the nervous system.
FDA Label Information
Monoamine Oxidase Inhibitors (MAOIs) The concomitant use of opioids and MAOIs, such as phenelzine, tranylcypromine, linezolid, may manifest as serotonin syndrome or opioid toxicity (e.g., respiratory depression, coma) [see WARNINGS ] .
Tranylcypromine Also Interacts With
- Bupropion major
- Linezolid major
- Vilazodone major
- Epinephrine major
- Norepinephrine major
Acetaminophen/Oxycodone Also Interacts With
- Gabapentin moderate
- Pregabalin moderate
- Trazodone minor
- Tramadol minor
- Cyclobenzaprine minor
Frequently Asked Questions
What SPL severity band is on file for Tranylcypromine + Acetaminophen/Oxycodone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Tranylcypromine has 42 labeled pairs on file vs Acetaminophen/Oxycodone's 23. In the minor band specifically: Tranylcypromine has 12 (also Fluoxetine, Buprenorphine, Buprenorphine/Naloxone, Buprenorphine); Acetaminophen/Oxycodone has 21 (also Trazodone, Tramadol, Cyclobenzaprine, Oxycodone).
What mechanism field is on file for Tranylcypromine and Acetaminophen/Oxycodone?
This combination can cause serious side effects like extreme sleepiness, breathing trouble, or a dangerous reaction in the brain. It happens because the two drugs interfere with each other's effects on the nervous system.
Tranylcypromine carries more major-labeled pairs than Acetaminophen/Oxycodone
SPL source-record counts only. This page's band is minor · classes on file: Tranylcypromine (Monoamine Oxidase Inhibitor (MAOI)); Acetaminophen/Oxycodone (Opioid Analgesic Combination).
Tranylcypromine has 7 major-labeled pairs vs Acetaminophen/Oxycodone's 0. This page itself is in the minor band, not the major band.
7 major · 23 moderate · 12 minor · 42 total
- Other minor peers for Tranylcypromine
- Fluoxetine
- Buprenorphine
- Buprenorphine/Naloxone
- Buprenorphine
0 major · 2 moderate · 21 minor · 23 total
- Other minor peers for Acetaminophen/Oxycodone
- Trazodone
- Tramadol
- Cyclobenzaprine
- Oxycodone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.