Tranylcypromine and Epinephrine Interaction
Drug interaction information between Tranylcypromine and Epinephrine.
Tranylcypromine and Epinephrine have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Tranylcypromine and Epinephrine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Tranylcypromine prevents the body from breaking down epinephrine, which can cause a sudden and dangerously high spike in blood pressure.
FDA Label Information
If in the absence of therapeutic alternatives and emergency treatment with a contraindicated drug (e.g., linezolid, intravenous methylene blue, direct-acting sympathomimetic drugs such as epinephrine) becomes necessary and cannot be delayed, discontinue tranylcypromine tablets as soon as possible before initiating treatment with the other agent, and monitor closely for adverse reactions. Excessive reduction of blood glucose (additive effect) [See Warnings and Precautions (5.14)] ; CNS depressant agents (including opioids, alcohol, sedatives, hypnotics) Use with caution Increased CNS...
Tranylcypromine Also Interacts With
- Bupropion major
- Linezolid major
- Vilazodone major
- Norepinephrine major
- Phenylephrine major
Epinephrine Also Interacts With
- Carbidopa/Levodopa moderate
- Digoxin moderate
- Imipramine moderate
- Levothyroxine minor
- Clonidine minor
Frequently Asked Questions
What SPL severity band is on file for Tranylcypromine + Epinephrine?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Tranylcypromine has 42 labeled pairs on file vs Epinephrine's 28. In the major band specifically: Tranylcypromine has 7 (also Bupropion, Linezolid, Vilazodone, Norepinephrine); Epinephrine has 1.
What mechanism field is on file for Tranylcypromine and Epinephrine?
Tranylcypromine prevents the body from breaking down epinephrine, which can cause a sudden and dangerously high spike in blood pressure.
Tranylcypromine carries more major-labeled pairs than Epinephrine
SPL source-record counts only. This page's band is major · classes on file: Tranylcypromine (Monoamine Oxidase Inhibitor (MAOI)); Epinephrine (Adrenergic Agonist).
Tranylcypromine has 7 major-labeled pairs vs Epinephrine's 1.
7 major · 23 moderate · 12 minor · 42 total
- Other major peers for Tranylcypromine
- Bupropion
- Linezolid
- Vilazodone
- Norepinephrine
1 major · 3 moderate · 24 minor · 28 total
Epinephrine has no other major-band peer in this dataset besides Tranylcypromine.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.