Tranylcypromine and Epinephrine Interaction
Drug interaction information between Tranylcypromine and Epinephrine.
Tranylcypromine and Epinephrine have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Tranylcypromine and Epinephrine. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Tranylcypromine prevents the body from breaking down epinephrine, which can cause a sudden and dangerously high spike in blood pressure.
What To Do
Avoid this combination unless it is a medical emergency. If used in an emergency, a doctor must monitor your blood pressure and heart rate very closely.
FDA Label Information
If in the absence of therapeutic alternatives and emergency treatment with a contraindicated drug (e.g., linezolid, intravenous methylene blue, direct-acting sympathomimetic drugs such as epinephrine) becomes necessary and cannot be delayed, discontinue tranylcypromine tablets as soon as possible before initiating treatment with the other agent, and monitor closely for adverse reactions. Excessive reduction of blood glucose (additive effect) [See Warnings and Precautions (5.14)] ; CNS depressant agents (including opioids, alcohol, sedatives, hypnotics) Use with caution Increased CNS...
Tranylcypromine Also Interacts With
- Bupropion major
- Linezolid major
- Vilazodone major
- Norepinephrine major
- Phenylephrine major
Epinephrine Also Interacts With
- Carbidopa/Levodopa moderate
- Digoxin moderate
- Imipramine moderate
- Levothyroxine minor
- Clonidine minor
Frequently Asked Questions
Can I take Tranylcypromine and Epinephrine together?
This is a major interaction. Avoid this combination unless it is a medical emergency. If used in an emergency, a doctor must monitor your blood pressure and heart rate very closely.
How serious is the interaction between Tranylcypromine and Epinephrine?
This interaction is classified as "major" severity by the FDA. Major interactions may be life-threatening or cause serious side effects.
Why do Tranylcypromine and Epinephrine interact?
Tranylcypromine prevents the body from breaking down epinephrine, which can cause a sudden and dangerously high spike in blood pressure.
Understanding the Tranylcypromine and Epinephrine Interaction
FDA-approved prescribing information for these two drugs flags their combination as a major-severity interaction. Tranylcypromine belongs to the Monoamine Oxidase Inhibitor (MAOI) class and Epinephrine belongs to the Adrenergic Agonist class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Tranylcypromine prevents the body from breaking down epinephrine, which can cause a sudden and dangerously high spike in blood pressure. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Tranylcypromine has 42 total documented interactions on file in this dataset, and Epinephrine has 28. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Avoid this combination unless it is a medical emergency. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Tranylcypromine or Epinephrine based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.