Tranylcypromine and Fluoxetine Interaction
Drug interaction information between Tranylcypromine and Fluoxetine.
Tranylcypromine and Fluoxetine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Tranylcypromine and Fluoxetine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fluoxetine stays in your system for a long time and can cause a dangerous reaction if it overlaps with this medicine.
FDA Label Information
This period can be several weeks long (e.g., a minimum of 5 weeks for fluoxetine given fluoxetine's long half-life).
Tranylcypromine Also Interacts With
- Bupropion major
- Linezolid major
- Vilazodone major
- Epinephrine major
- Norepinephrine major
Fluoxetine Also Interacts With
- Aspirin major
- Warfarin major
- Olanzapine major
- Pimozide major
- Thioridazine major
Frequently Asked Questions
What SPL severity band is on file for Tranylcypromine + Fluoxetine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluoxetine has 68 labeled pairs on file vs Tranylcypromine's 42. In the minor band specifically: Tranylcypromine has 12 (also Acetaminophen/Oxycodone, Buprenorphine, Buprenorphine/Naloxone, Buprenorphine); Fluoxetine has 43 (also Ketoconazole, Lithium, Moxifloxacin, Erythromycin).
What mechanism field is on file for Tranylcypromine and Fluoxetine?
Fluoxetine stays in your system for a long time and can cause a dangerous reaction if it overlaps with this medicine.
Tranylcypromine carries more major-labeled pairs than Fluoxetine
SPL source-record counts only. This page's band is minor · classes on file: Tranylcypromine (Monoamine Oxidase Inhibitor (MAOI)); Fluoxetine (Selective Serotonin Reuptake Inhibitor (SSRI)).
Tranylcypromine has 7 major-labeled pairs vs Fluoxetine's 6. This page itself is in the minor band, not the major band.
7 major · 23 moderate · 12 minor · 42 total
- Other minor peers for Tranylcypromine
- Acetaminophen/Oxycodone
- Buprenorphine
- Buprenorphine/Naloxone
- Buprenorphine
6 major · 19 moderate · 43 minor · 68 total
- Other minor peers for Fluoxetine
- Ketoconazole
- Lithium
- Moxifloxacin
- Erythromycin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.