Tranylcypromine and Bupropion Interaction
Drug interaction information between Tranylcypromine and Bupropion.
Tranylcypromine and Bupropion have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Tranylcypromine and Bupropion. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These two antidepressants can cause a severe reaction when used at the same time. They both change brain chemicals in a way that can lead to dangerously high blood pressure.
FDA Label Information
Excessive reduction of blood glucose (additive effect) [See Warnings and Precautions (5.14)] ; CNS depressant agents (including opioids, alcohol, sedatives, hypnotics) Use with caution Increased CNS depression Dietary supplements containing sympathomimetics Contraindicated Antidepressants including but not limited to: • Other MAOIs (e.g., linezolid, intravenous methylene blue, selective MAOIs) • Selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs) • Tricyclic antidepressants • Amoxapine, bupropion, maprotiline, nefazodone, trazodone,...
Tranylcypromine Also Interacts With
- Linezolid major
- Vilazodone major
- Epinephrine major
- Norepinephrine major
- Phenylephrine major
Bupropion Also Interacts With
- Theophylline moderate
- Isavuconazonium moderate
- Metoprolol minor
- Sertraline minor
- Fluoxetine minor
Frequently Asked Questions
What SPL severity band is on file for Tranylcypromine + Bupropion?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Tranylcypromine has 42 labeled pairs on file vs Bupropion's 35. In the major band specifically: Tranylcypromine has 7 (also Linezolid, Vilazodone, Epinephrine, Norepinephrine); Bupropion has 1.
What mechanism field is on file for Tranylcypromine and Bupropion?
These two antidepressants can cause a severe reaction when used at the same time. They both change brain chemicals in a way that can lead to dangerously high blood pressure.
Tranylcypromine carries more major-labeled pairs than Bupropion
SPL source-record counts only. This page's band is major · classes on file: Tranylcypromine (Monoamine Oxidase Inhibitor (MAOI)); Bupropion (Norepinephrine-Dopamine Reuptake Inhibitor (NDRI)).
Tranylcypromine has 7 major-labeled pairs vs Bupropion's 1.
7 major · 23 moderate · 12 minor · 42 total
- Other major peers for Tranylcypromine
- Linezolid
- Vilazodone
- Epinephrine
- Norepinephrine
1 major · 2 moderate · 32 minor · 35 total
Bupropion has no other major-band peer in this dataset besides Tranylcypromine.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.