Tranylcypromine and Buprenorphine Interaction
Drug interaction information between Tranylcypromine and Buprenorphine.
Tranylcypromine and Buprenorphine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Tranylcypromine and Buprenorphine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These medicines together can cause a serious brain reaction and make it harder for you to breathe. It can also lead to high fever or muscle stiffness.
FDA Label Information
Examples: phenelzine, tranylcypromine, linezolid Muscle Relaxants Clinical Impact: Buprenorphine may enhance the neuromuscular blocking action of skeletal muscle relaxants and produce an increased degree of respiratory depression.
Tranylcypromine Also Interacts With
- Bupropion major
- Linezolid major
- Vilazodone major
- Epinephrine major
- Norepinephrine major
Buprenorphine Also Interacts With
- Oxycodone moderate
- Trazodone minor
- Cyclobenzaprine minor
- Mirtazapine minor
- Ketoconazole minor
Frequently Asked Questions
What SPL severity band is on file for Tranylcypromine + Buprenorphine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Tranylcypromine has 42 labeled pairs on file vs Buprenorphine's 29. In the minor band specifically: Tranylcypromine has 12 (also Fluoxetine, Acetaminophen/Oxycodone, Buprenorphine/Naloxone, Buprenorphine); Buprenorphine has 28 (also Trazodone, Cyclobenzaprine, Mirtazapine, Ketoconazole).
What mechanism field is on file for Tranylcypromine and Buprenorphine?
These medicines together can cause a serious brain reaction and make it harder for you to breathe. It can also lead to high fever or muscle stiffness.
Tranylcypromine carries more major-labeled pairs than Buprenorphine
SPL source-record counts only. This page's band is minor · classes on file: Tranylcypromine (Monoamine Oxidase Inhibitor (MAOI)); Buprenorphine (Partial Opioid Agonist).
Tranylcypromine has 7 major-labeled pairs vs Buprenorphine's 0. This page itself is in the minor band, not the major band.
7 major · 23 moderate · 12 minor · 42 total
- Other minor peers for Tranylcypromine
- Fluoxetine
- Acetaminophen/Oxycodone
- Buprenorphine/Naloxone
- Buprenorphine
0 major · 1 moderate · 28 minor · 29 total
- Other minor peers for Buprenorphine
- Trazodone
- Cyclobenzaprine
- Mirtazapine
- Ketoconazole
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.