acetaminophen/oxycodone vs tranylcypromine
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Side-by-side comparison of acetaminophen/oxycodone and tranylcypromine. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Monoamine Oxidase Inhibitors (MAOIs) The concomitant use of opioids and MAOIs, such as phenelzine, tranylcypromine, linezolid, may manifest as serotonin syndrome or opioid toxicity (e.g., respiratory depression, coma) [see WARNINGS ] .
Percocet
Parnate
Percocet is a strong pain medicine. It contains acetaminophen and oxycodone, an opioid.
Tranylcypromine (Parnate) is a medicine used to treat major depression in adults. It is used when other antidepressants have not worked well enough.
Percocet is used to manage severe pain. It is for pain that requires an opioid medicine. You should only use Percocet if other pain treatments don't work well enough.
Tranylcypromine is used to treat major depressive disorder (MDD) in adults. You should only use it if other antidepressants haven't helped. It is not for the first treatment of depression because it can cause serious side effects and has many drug and food interactions.
Oxycodone works in the brain to block pain signals. Acetaminophen also helps to reduce pain and fever. Together, they provide stronger pain relief.
Tranylcypromine belongs to a class of drugs called MAO inhibitors. It works by increasing the levels of certain chemicals in your brain. These chemicals can help improve your mood.
- • Lightheadedness
- • Dizziness
- • Drowsiness
- • Nausea
- • Vomiting
- • Dry mouth
- • Dizziness
- • Trouble sleeping
- • Feeling sleepy
- • Headache
- Tiredness 34,486
- Feeling sick to your stomach 29,571
- Head pain 28,378
- Aches 28,322
- Loose stools 23,628
- Drug Interaction 68
- Depression 36
- Serotonin Syndrome 27
- Headache 24
- Hypertension 24
Percocet has a boxed warning. It can cause addiction, abuse, and misuse, leading to overdose and death. It can also cause life-threatening breathing problems, especially when starting or increasing the dose. Accidental ingestion, even one dose, can cause a fatal overdose, especially in children. Taking Percocet with benzodiazepines or other CNS depressants, including alcohol, can cause severe sedation, breathing problems, coma, and death. Using opioids for a long time during pregnancy can cause withdrawal symptoms in the newborn. Acetaminophen can cause liver damage if you take too much.
Tranylcypromine can increase the risk of suicidal thoughts and behaviors in young adults. It can also cause a dangerous increase in blood pressure if you eat foods high in tyramine or take certain medicines. Make sure to follow all food and drug restrictions.
Taking Percocet for a long time during pregnancy can cause withdrawal symptoms in the baby after birth. Make sure a newborn specialist is available when you deliver your baby.
There is limited information about the safety of tranylcypromine during pregnancy. Talk to your doctor if you are pregnant or plan to become pregnant. It is not recommended to breastfeed while taking this medicine because it can harm the baby.
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How to Read This acetaminophen/oxycodone vs tranylcypromine Comparison
acetaminophen/oxycodone is classified in the Opioid Analgesic Combination drug class, while tranylcypromine sits within the Monoamine Oxidase Inhibitor (MAOI) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, acetaminophen/oxycodone has 144,385 submissions while tranylcypromine has 179. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to this combination can cause serious side effects like extreme sleepiness, breathing trouble, or a dangerous reaction in the brain. it happens because the two drugs interfere with each other's effects on the nervous system.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for acetaminophen/oxycodone or tranylcypromine.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.