Tranylcypromine and Buprenorphine/Naloxone Interaction
Drug interaction information between Tranylcypromine and Buprenorphine/Naloxone.
Tranylcypromine and Buprenorphine/Naloxone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Tranylcypromine and Buprenorphine/Naloxone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These drugs together can lead to a serious condition called serotonin syndrome or cause you to breathe too slowly.
FDA Label Information
Examples: phenelzine, tranylcypromine, linezolid Muscle Relaxants Clinical Impact: Buprenorphine may enhance the neuromuscular blocking action of skeletal muscle relaxants and produce an increased degree of respiratory depression.
Tranylcypromine Also Interacts With
- Bupropion major
- Linezolid major
- Vilazodone major
- Epinephrine major
- Norepinephrine major
Buprenorphine/Naloxone Also Interacts With
- Gabapentin minor
- Trazodone minor
- Tramadol minor
- Cyclobenzaprine minor
- Pregabalin minor
Frequently Asked Questions
What SPL severity band is on file for Tranylcypromine + Buprenorphine/Naloxone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Tranylcypromine has 42 labeled pairs on file vs Buprenorphine/Naloxone's 19. In the minor band specifically: Tranylcypromine has 12 (also Fluoxetine, Acetaminophen/Oxycodone, Buprenorphine, Buprenorphine); Buprenorphine/Naloxone has 19 (also Gabapentin, Trazodone, Tramadol, Cyclobenzaprine).
What mechanism field is on file for Tranylcypromine and Buprenorphine/Naloxone?
These drugs together can lead to a serious condition called serotonin syndrome or cause you to breathe too slowly.
Tranylcypromine carries more major-labeled pairs than Buprenorphine/Naloxone
SPL source-record counts only. This page's band is minor · classes on file: Tranylcypromine (Monoamine Oxidase Inhibitor (MAOI)); Buprenorphine/Naloxone (Partial Opioid Agonist / Antagonist).
Tranylcypromine has 7 major-labeled pairs vs Buprenorphine/Naloxone's 0. This page itself is in the minor band, not the major band.
7 major · 23 moderate · 12 minor · 42 total
- Other minor peers for Tranylcypromine
- Fluoxetine
- Acetaminophen/Oxycodone
- Buprenorphine
- Buprenorphine
0 major · 0 moderate · 19 minor · 19 total
- Other minor peers for Buprenorphine/Naloxone
- Gabapentin
- Trazodone
- Tramadol
- Cyclobenzaprine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.