Tranylcypromine and Vilazodone Interaction
Drug interaction information between Tranylcypromine and Vilazodone.
Tranylcypromine and Vilazodone have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Tranylcypromine and Vilazodone. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Both drugs increase serotonin levels in the brain, which can lead to a dangerous and life-threatening condition called serotonin syndrome.
What To Do
Do not take these medications together. Your doctor will typically require a waiting period of at least 14 days when switching between them.
FDA Label Information
Excessive reduction of blood glucose (additive effect) [See Warnings and Precautions (5.14)] ; CNS depressant agents (including opioids, alcohol, sedatives, hypnotics) Use with caution Increased CNS depression Dietary supplements containing sympathomimetics Contraindicated Antidepressants including but not limited to: • Other MAOIs (e.g., linezolid, intravenous methylene blue, selective MAOIs) • Selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs) • Tricyclic antidepressants • Amoxapine, bupropion, maprotiline, nefazodone, trazodone,...
Tranylcypromine Also Interacts With
- Bupropion major
- Linezolid major
- Epinephrine major
- Norepinephrine major
- Phenylephrine major
Vilazodone Also Interacts With
- Linezolid major
- Warfarin moderate
- Carbamazepine minor
- Clarithromycin minor
- Rifampin minor
Frequently Asked Questions
Can I take Tranylcypromine and Vilazodone together?
This is a major interaction. Do not take these medications together. Your doctor will typically require a waiting period of at least 14 days when switching between them.
How serious is the interaction between Tranylcypromine and Vilazodone?
This interaction is classified as "major" severity by the FDA. Major interactions may be life-threatening or cause serious side effects.
Why do Tranylcypromine and Vilazodone interact?
Both drugs increase serotonin levels in the brain, which can lead to a dangerous and life-threatening condition called serotonin syndrome.
Understanding the Tranylcypromine and Vilazodone Interaction
FDA-approved prescribing information for these two drugs flags their combination as a major-severity interaction. Tranylcypromine belongs to the Monoamine Oxidase Inhibitor (MAOI) class and Vilazodone belongs to the SSRI / 5-HT1A Partial Agonist class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Both drugs increase serotonin levels in the brain, which can lead to a dangerous and life-threatening condition called serotonin syndrome. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Tranylcypromine has 42 total documented interactions on file in this dataset, and Vilazodone has 10. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Do not take these medications together. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Tranylcypromine or Vilazodone based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.