Torsemide and Celecoxib Interaction
Drug interaction information between Torsemide and Celecoxib.
Torsemide and Celecoxib have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Torsemide and Celecoxib. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Torsemide slows down the liver's ability to process celecoxib, which can affect how safe or effective the drug is.
FDA Label Information
Because of its inhibition of CYP2C9 metabolism, torsemide may affect the efficacy and safety of sensitive CYP2C9 substrates, such as celecoxib, or of substrates with a narrow therapeutic range, such as warfarin or phenytoin.
Torsemide Also Interacts With
- Lithium moderate
- Warfarin minor
- Fluconazole minor
- Rifampin minor
- Amiodarone minor
Celecoxib Also Interacts With
- Methotrexate moderate
- Diflunisal moderate
- Heparin moderate
- Meloxicam minor
- Furosemide minor
Frequently Asked Questions
What SPL severity band is on file for Torsemide + Celecoxib?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Celecoxib has 19 labeled pairs on file vs Torsemide's 11. In the minor band specifically: Torsemide has 10 (also Warfarin, Fluconazole, Rifampin, Amiodarone); Celecoxib has 16 (also Meloxicam, Furosemide, Aspirin, Propranolol).
What mechanism field is on file for Torsemide and Celecoxib?
Torsemide slows down the liver's ability to process celecoxib, which can affect how safe or effective the drug is.
Celecoxib's labeled portfolio outnumbers Torsemide
SPL source-record counts only. This page's band is minor · classes on file: Torsemide (Loop Diuretic); Celecoxib (COX-2 Selective NSAID).
0 major · 1 moderate · 10 minor · 11 total
- Other minor peers for Torsemide
- Warfarin
- Fluconazole
- Rifampin
- Amiodarone
0 major · 3 moderate · 16 minor · 19 total
- Other minor peers for Celecoxib
- Meloxicam
- Furosemide
- Aspirin
- Propranolol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.