celecoxib vs torsemide
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Side-by-side comparison of celecoxib and torsemide. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Because of its inhibition of CYP2C9 metabolism, torsemide may affect the efficacy and safety of sensitive CYP2C9 substrates, such as celecoxib, or of substrates with a narrow therapeutic range, such as warfarin or phenytoin.
Celecoxib (Celebrex) is a medicine that reduces pain and swelling. It belongs to a class of drugs called NSAIDs.
Torsemide is a water pill (diuretic). It helps remove extra fluid from your body and lowers blood pressure.
Celecoxib treats the symptoms of osteoarthritis and rheumatoid arthritis. It can also help with juvenile rheumatoid arthritis in children 2 years and older. Additionally, it is used for ankylosing spondylitis, acute pain, and menstrual pain.
Torsemide treats swelling from heart, kidney, or liver problems. It also treats high blood pressure. Lowering blood pressure helps prevent strokes and heart attacks. Managing high blood pressure should include healthy habits like diet and exercise.
Celecoxib blocks a substance in the body that causes pain and swelling. It targets COX-2, an enzyme involved in inflammation. By blocking COX-2, celecoxib reduces inflammation and relieves pain.
Torsemide works in your kidneys to help your body get rid of extra salt and water. This lowers the amount of fluid in your body. As a result, this can lower your blood pressure.
- • Abdominal pain
- • Diarrhea
- • Upset stomach
- • Gas
- • Swelling in your legs or feet
- • Excessive urination
- Pain 12,294
- Arthralgia 10,923
- Fatigue 9,710
- Nausea 9,389
- Drug Hypersensitivity 7,713
- Dyspnoea 3,305
- Fatigue 2,066
- Nausea 1,927
- Diarrhoea 1,916
- Dizziness 1,823
Celecoxib may increase your risk of serious heart problems like heart attack and stroke, which can be fatal. This risk may happen early in treatment and increases with longer use. You should not take celecoxib if you are having heart bypass surgery. Celecoxib can also increase the risk of serious stomach and intestine problems like bleeding, ulcers, and holes, which can be fatal. These problems can happen without warning. The elderly and those with a history of ulcers or GI bleeding are at higher risk.
Torsemide can cause you to lose too much fluid. This can lead to low blood pressure and kidney problems. Your doctor should check your fluid levels and kidney function. Torsemide can also cause problems with electrolytes (like potassium) and blood sugar. Your doctor should check these regularly.
Using celecoxib after about 20 weeks of pregnancy can cause kidney problems in the baby and low amniotic fluid. Avoid using celecoxib after 30 weeks of pregnancy because it can cause the baby's heart to close too early. If you are trying to get pregnant, talk to your doctor, as celecoxib may affect fertility.
It is not known if torsemide will harm an unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. It is also not known if torsemide passes into breast milk. Talk to your doctor about the best way to feed your baby if you are taking this medicine, as diuretics may reduce breast milk production.
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How to Read This celecoxib vs torsemide Comparison
celecoxib is classified in the COX-2 Selective NSAID drug class, while torsemide sits within the Loop Diuretic class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, celecoxib has 50,029 submissions while torsemide has 11,037. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to torsemide slows down the liver's ability to process celecoxib, which can affect how safe or effective the drug is.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for celecoxib or torsemide.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.