Torsemide and Amiodarone Interaction
Drug interaction information between Torsemide and Amiodarone.
Torsemide and Amiodarone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Torsemide and Amiodarone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Amiodarone slows down how your body processes torsemide. This can lead to higher-than-normal levels of the drug in your blood.
FDA Label Information
Concomitant use of CYP2C9 inhibitors (e.g., amiodarone, fluconazole, miconazole, oxandrolone) can decrease torsemide clearance and increase torsemide plasma concentrations.
Torsemide Also Interacts With
- Lithium moderate
- Celecoxib minor
- Warfarin minor
- Fluconazole minor
- Rifampin minor
Amiodarone Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Nirmatrelvir/Ritonavir major
- Simvastatin major
- Lithium moderate
Frequently Asked Questions
What SPL severity band is on file for Torsemide + Amiodarone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Amiodarone has 42 labeled pairs on file vs Torsemide's 11. In the minor band specifically: Torsemide has 10 (also Celecoxib, Warfarin, Fluconazole, Rifampin); Amiodarone has 29 (also Atorvastatin, Clonidine, Diltiazem, Verapamil).
What mechanism field is on file for Torsemide and Amiodarone?
Amiodarone slows down how your body processes torsemide. This can lead to higher-than-normal levels of the drug in your blood.
Amiodarone carries more major-labeled pairs than Torsemide
SPL source-record counts only. This page's band is minor · classes on file: Torsemide (Loop Diuretic); Amiodarone (Class III Antiarrhythmic).
Amiodarone has 4 major-labeled pairs vs Torsemide's 0. This page itself is in the minor band, not the major band.
0 major · 1 moderate · 10 minor · 11 total
- Other minor peers for Torsemide
- Celecoxib
- Warfarin
- Fluconazole
- Rifampin
4 major · 9 moderate · 29 minor · 42 total
- Other minor peers for Amiodarone
- Atorvastatin
- Clonidine
- Diltiazem
- Verapamil
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.