Celecoxib and Diflunisal Interaction
Drug interaction information between Celecoxib and Diflunisal.
Celecoxib and Diflunisal have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Celecoxib and Diflunisal. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs are similar types of pain relievers that can harm the stomach lining. Taking them together increases the risk of stomach problems without helping your pain any more than one drug alone.
FDA Label Information
NSAIDs and Salicylates Clinical Impact: Concomitant use of Celecoxib with other NSAIDs or salicylates (e.g., diflunisal, salsalate) increases the risk of GI toxicity, with little or no increase in efficacy [ see Warnings and Precautions (5.2) ] .
Celecoxib Also Interacts With
- Methotrexate moderate
- Heparin moderate
- Meloxicam minor
- Furosemide minor
- Aspirin minor
Diflunisal Also Interacts With
- Methotrexate moderate
- Cyclosporine moderate
- Indomethacin moderate
- Mefenamic Acid moderate
- Meloxicam moderate
Frequently Asked Questions
What SPL severity band is on file for Celecoxib + Diflunisal?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Celecoxib has 19 labeled pairs on file vs Diflunisal's 17. In the moderate band specifically: Celecoxib has 3 (also Methotrexate, Heparin); Diflunisal has 11 (also Methotrexate, Cyclosporine, Indomethacin, Mefenamic Acid).
What mechanism field is on file for Celecoxib and Diflunisal?
Both drugs are similar types of pain relievers that can harm the stomach lining. Taking them together increases the risk of stomach problems without helping your pain any more than one drug alone.
Celecoxib's labeled portfolio outnumbers Diflunisal
SPL source-record counts only. This page's band is moderate · classes on file: Celecoxib (COX-2 Selective NSAID); Diflunisal (Nonsteroidal Anti-Inflammatory Drug (NSAID)).
0 major · 3 moderate · 16 minor · 19 total
- Other moderate peers for Celecoxib
- Methotrexate
- Heparin
0 major · 11 moderate · 6 minor · 17 total
- Other moderate peers for Diflunisal
- Methotrexate
- Cyclosporine
- Indomethacin
- Mefenamic Acid
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.