Torsemide and Warfarin Interaction
Drug interaction information between Torsemide and Warfarin.
Torsemide and Warfarin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Torsemide and Warfarin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Torsemide interferes with the way your liver breaks down warfarin, which can cause the drug to build up or work differently.
FDA Label Information
Torsemide may affect the efficacy and safety of sensitive CYP2C9 substrates or of substrates with a narrow therapeutic range, such as warfarin or phenytoin. Because of its inhibition of CYP2C9 metabolism, torsemide may affect the efficacy and safety of sensitive CYP2C9 substrates, such as celecoxib, or of substrates with a narrow therapeutic range, such as warfarin or phenytoin.
Torsemide Also Interacts With
- Lithium moderate
- Celecoxib minor
- Fluconazole minor
- Rifampin minor
- Amiodarone minor
Warfarin Also Interacts With
- Fluoxetine major
- Tamoxifen major
- Ibuprofen moderate
- Aspirin moderate
- Diclofenac moderate
Frequently Asked Questions
What SPL severity band is on file for Torsemide + Warfarin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Warfarin has 163 labeled pairs on file vs Torsemide's 11. In the minor band specifically: Torsemide has 10 (also Celecoxib, Fluconazole, Rifampin, Amiodarone); Warfarin has 133 (also Atorvastatin, Amlodipine, Omeprazole, Famotidine).
What mechanism field is on file for Torsemide and Warfarin?
Torsemide interferes with the way your liver breaks down warfarin, which can cause the drug to build up or work differently.
Warfarin carries more major-labeled pairs than Torsemide
SPL source-record counts only. This page's band is minor · classes on file: Torsemide (Loop Diuretic); Warfarin (Vitamin K Antagonist (Anticoagulant)).
Warfarin has 2 major-labeled pairs vs Torsemide's 0. This page itself is in the minor band, not the major band.
0 major · 1 moderate · 10 minor · 11 total
- Other minor peers for Torsemide
- Celecoxib
- Fluconazole
- Rifampin
- Amiodarone
2 major · 28 moderate · 133 minor · 163 total
- Other minor peers for Warfarin
- Atorvastatin
- Amlodipine
- Omeprazole
- Famotidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.