Celecoxib and Propranolol Interaction
Drug interaction information between Celecoxib and Propranolol.
Celecoxib and Propranolol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Celecoxib and Propranolol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This pain medicine can make your blood pressure medication less effective, which could cause your blood pressure to rise.
FDA Label Information
ACE Inhibitors, Angiotensin Receptor Blockers, and Beta-Blockers Clinical Impact: NSAIDs may diminish the antihypertensive effect of ACE inhibitors, ARBs, or beta-blockers (including propranolol).
Celecoxib Also Interacts With
- Methotrexate moderate
- Diflunisal moderate
- Heparin moderate
- Meloxicam minor
- Furosemide minor
Frequently Asked Questions
What SPL severity band is on file for Celecoxib + Propranolol?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Propranolol has 44 labeled pairs on file vs Celecoxib's 19. In the minor band specifically: Celecoxib has 16 (also Meloxicam, Furosemide, Aspirin, Diclofenac); Propranolol has 44 (also Clonidine, Diltiazem, Warfarin, Verapamil).
What mechanism field is on file for Celecoxib and Propranolol?
This pain medicine can make your blood pressure medication less effective, which could cause your blood pressure to rise.
Propranolol's labeled portfolio outnumbers Celecoxib
SPL source-record counts only. This page's band is minor · classes on file: Celecoxib (COX-2 Selective NSAID); Propranolol (Non-Selective Beta-Blocker).
0 major · 3 moderate · 16 minor · 19 total
- Other minor peers for Celecoxib
- Meloxicam
- Furosemide
- Aspirin
- Diclofenac
0 major · 0 moderate · 44 minor · 44 total
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.