Torsemide and Rifampin Interaction
Drug interaction information between Torsemide and Rifampin.
Torsemide and Rifampin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Torsemide and Rifampin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Rifampin speeds up the process of removing torsemide from your body. This can make the torsemide less effective.
FDA Label Information
Concomitant use of CYP2C9 inducers (e.g., rifampin) increase torsemide clearance and decrease plasma torsemide concentrations.
Torsemide Also Interacts With
- Lithium moderate
- Celecoxib minor
- Warfarin minor
- Fluconazole minor
- Amiodarone minor
Rifampin Also Interacts With
- Darunavir major
- Bictegravir/Emtricitabine/Tenofovir major
- Glecaprevir/Pibrentasvir major
- Nirmatrelvir/Ritonavir major
- Pitavastatin major
Frequently Asked Questions
What SPL severity band is on file for Torsemide + Rifampin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Rifampin has 137 labeled pairs on file vs Torsemide's 11. In the minor band specifically: Torsemide has 10 (also Celecoxib, Warfarin, Fluconazole, Amiodarone); Rifampin has 103 (also Metoprolol, Losartan, Simvastatin, Glipizide).
What mechanism field is on file for Torsemide and Rifampin?
Rifampin speeds up the process of removing torsemide from your body. This can make the torsemide less effective.
Rifampin carries more major-labeled pairs than Torsemide
SPL source-record counts only. This page's band is minor · classes on file: Torsemide (Loop Diuretic); Rifampin (Rifamycin Antibiotic).
Rifampin has 8 major-labeled pairs vs Torsemide's 0. This page itself is in the minor band, not the major band.
0 major · 1 moderate · 10 minor · 11 total
- Other minor peers for Torsemide
- Celecoxib
- Warfarin
- Fluconazole
- Amiodarone
8 major · 26 moderate · 103 minor · 137 total
- Other minor peers for Rifampin
- Metoprolol
- Losartan
- Simvastatin
- Glipizide
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.