Celecoxib and Aspirin Interaction
Drug interaction information between Celecoxib and Aspirin.
Celecoxib and Aspirin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Celecoxib and Aspirin. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Using these two medicines together does not provide more pain relief but does increase the risk of developing stomach ulcers or bleeding.
What To Do
Monitor yourself for signs of bleeding and consult your doctor to see if you need to take both of these medications.
FDA Label Information
Intervention: Monitor patients with concomitant use of celecoxib with anticoagulants (e.g., warfarin), antiplatelet drugs (e.g., aspirin), SSRIs, and SNRIs for signs of bleeding [see Warnings and Precautions (5.12) ]. Aspirin Clinical Impact: Controlled clinical studies showed that the concomitant use of NSAIDs and analgesic doses of aspirin does not produce any greater therapeutic effect than the use of NSAIDs alone. In a clinical study, the concomitant use of an NSAID and aspirin was associated with a significantly increased incidence of GI adverse reactions as compared to use of the...
Celecoxib Also Interacts With
- Methotrexate moderate
- Diflunisal moderate
- Heparin moderate
- Meloxicam minor
- Furosemide minor
Aspirin Also Interacts With
- Atenolol major
- Fluoxetine major
- Ibandronate major
- Alendronate moderate
- Apixaban moderate
Frequently Asked Questions
Can I take Celecoxib and Aspirin together?
This is a minor interaction. Monitor yourself for signs of bleeding and consult your doctor to see if you need to take both of these medications.
How serious is the interaction between Celecoxib and Aspirin?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Celecoxib and Aspirin interact?
Using these two medicines together does not provide more pain relief but does increase the risk of developing stomach ulcers or bleeding.
Understanding the Celecoxib and Aspirin Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Celecoxib belongs to the COX-2 Selective NSAID class and Aspirin belongs to the Antiplatelet / NSAID class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Using these two medicines together does not provide more pain relief but does increase the risk of developing stomach ulcers or bleeding. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Celecoxib has 19 total documented interactions on file in this dataset, and Aspirin has 47. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Monitor yourself for signs of bleeding and consult your doctor to see if you need to take both of these medications. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Celecoxib or Aspirin based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.