Celecoxib and Aspirin Interaction
Drug interaction information between Celecoxib and Aspirin.
Celecoxib and Aspirin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Celecoxib and Aspirin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Using these two medicines together does not provide more pain relief but does increase the risk of developing stomach ulcers or bleeding.
FDA Label Information
Intervention: Monitor patients with concomitant use of celecoxib with anticoagulants (e.g., warfarin), antiplatelet drugs (e.g., aspirin), SSRIs, and SNRIs for signs of bleeding [see Warnings and Precautions (5.12) ]. Aspirin Clinical Impact: Controlled clinical studies showed that the concomitant use of NSAIDs and analgesic doses of aspirin does not produce any greater therapeutic effect than the use of NSAIDs alone. In a clinical study, the concomitant use of an NSAID and aspirin was associated with a significantly increased incidence of GI adverse reactions as compared to use of the...
Celecoxib Also Interacts With
- Methotrexate moderate
- Diflunisal moderate
- Heparin moderate
- Meloxicam minor
- Furosemide minor
Aspirin Also Interacts With
- Atenolol major
- Fluoxetine major
- Ibandronate major
- Alendronate moderate
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Celecoxib + Aspirin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Aspirin has 47 labeled pairs on file vs Celecoxib's 19. In the minor band specifically: Celecoxib has 16 (also Meloxicam, Furosemide, Propranolol, Diclofenac); Aspirin has 32 (also Carisoprodol, Colestipol, Diflunisal, Edoxaban).
What mechanism field is on file for Celecoxib and Aspirin?
Using these two medicines together does not provide more pain relief but does increase the risk of developing stomach ulcers or bleeding.
Aspirin carries more major-labeled pairs than Celecoxib
SPL source-record counts only. This page's band is minor · classes on file: Celecoxib (COX-2 Selective NSAID); Aspirin (Antiplatelet / NSAID).
Aspirin has 3 major-labeled pairs vs Celecoxib's 0. This page itself is in the minor band, not the major band.
0 major · 3 moderate · 16 minor · 19 total
- Other minor peers for Celecoxib
- Meloxicam
- Furosemide
- Propranolol
- Diclofenac
3 major · 12 moderate · 32 minor · 47 total
- Other minor peers for Aspirin
- Carisoprodol
- Colestipol
- Diflunisal
- Edoxaban
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.