What the FDA labels say about taking them together
Aspirin and celecoxib
Celecoxib's FDA label of November 22, 2024 names aspirin in its contraindications section; aspirin's label does not name celecoxib itself but warns about its class (NSAIDs (nonsteroidal anti-inflammatory drugs)). The celecoxib label: “• Celecoxib and anticoagulants such as warfarin have a synergistic effect on bleeding. The concomitant use of Celecoxib and anticoagulants have an increased risk of serious bleeding compared to the use of either drug …”
Check it at the source: the aspirin FDA label on DailyMed (effective September 9, 2025); the celecoxib FDA label on DailyMed (effective November 22, 2024, Viatris Specialty LLC).
What does the aspirin label say about celecoxib?
Aspirin's label does not name celecoxib itself; it warns about its class (NSAIDs (nonsteroidal anti-inflammatory drugs)):
Aspirin label, warningsThis product contains an NSAID, which may cause severe stomach bleeding.
Aspirin label, warningsThe chance is higher if you: are age 60 or older have had stomach ulcers or bleeding problems take a blood thinning (anticoagulant) or steroid drug take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others) have 3 or more alcohol drinks every day while using this product take more or for a longer time than directed
Source: FDA drug label (Medique Products Aspirin), Unifirst First Aid Corporation, effective September 9, 2025 (SPL set 9b28fed0-a993-ca72-e053-2995a90ac7fd), via openFDA; the full label on DailyMed
What does the celecoxib label say about aspirin?
Celecoxib label, contraindicationsHistory of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs.
Celecoxib label, drug interactionsDrugs that Interfere with Hemostasis Clinical Impact: • Celecoxib and anticoagulants such as warfarin have a synergistic effect on bleeding. The concomitant use of Celecoxib and anticoagulants have an increased risk of serious bleeding compared to the use of either drug alone. • Serotonin release by platelets plays an important role in hemostasis. … Intervention: Monitor patients with concomitant use of CELEBREX with anticoagulants (e.g., warfarin), antiplatelet drugs (e.g., aspirin), SSRIs, and SNRIs for signs of bleeding [see ].
Celecoxib label, warnings and precautionsExacerbation of Asthma Related to Aspirin Sensitivity: CELEBREX is contraindicated in patients with aspirin-sensitive asthma.
Elyxyb - Celecoxib label (SCILEX PHARMACEUTICALS INC., November 26, 2024), drug interactionsIntervention; Monitor patients with concomitant use of ELYXYB with anticoagulants (e.g., warfarin), antiplatelet drugs (e.g., aspirin), SSRIs, and SNRIs for signs of bleeding [see Warnings and Precautions ()].
Elyxyb - Celecoxib label (SCILEX PHARMACEUTICALS INC., November 26, 2024), warnings and precautionsMonitor patients with preexisting asthma (without aspirin sensitivity) ( 5.8 ) Serious Skin Reactions:
Source: FDA drug label (Vyscoxa, NDA211759), Carwin Pharmaceutical Associates, LLC, effective July 31, 2025 (SPL set 5094d47e-f791-4190-9397-b7500143a74d), via openFDA
Source: FDA drug label (CELEBREX), NDA020998 (Upjohn), as published by Viatris Specialty LLC, effective November 22, 2024 (SPL set 2d6675e4-5859-4be2-8037-a20ce9f707aa), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aspirin | Celecoxib | |
|---|---|---|
| Labeled for | Pain, Cough and cold, Fever | Osteoarthritis, Rheumatoid arthritis, Pain, Migraine |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.0142 per tablet 81 mg tablet | $0.0762 per capsule 200 mg capsule |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once