Celecoxib and Methotrexate Interaction
Drug interaction information between Celecoxib and Methotrexate.
Celecoxib and Methotrexate have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Celecoxib and Methotrexate. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Celecoxib can make methotrexate more harmful to your blood and kidneys. This happens even though the amount of methotrexate in your blood stays the same.
FDA Label Information
Methotrexate Clinical Impact: Concomitant use of NSAIDs and methotrexate may increase the risk for methotrexate toxicity (e.g., neutropenia, thrombocytopenia, renal dysfunction). Celecoxib has no effect on methotrexate pharmacokinetics. Intervention: During concomitant use of celecoxib and methotrexate, monitor patients for methotrexate toxicity.
Celecoxib Also Interacts With
- Diflunisal moderate
- Heparin moderate
- Meloxicam minor
- Furosemide minor
- Aspirin minor
Methotrexate Also Interacts With
- Diflunisal moderate
- Indomethacin moderate
- Mefenamic Acid moderate
- Meloxicam moderate
- Misoprostol moderate
Frequently Asked Questions
What SPL severity band is on file for Celecoxib + Methotrexate?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Methotrexate has 38 labeled pairs on file vs Celecoxib's 19. In the moderate band specifically: Celecoxib has 3 (also Diflunisal, Heparin); Methotrexate has 12 (also Diflunisal, Indomethacin, Mefenamic Acid, Meloxicam).
What mechanism field is on file for Celecoxib and Methotrexate?
Celecoxib can make methotrexate more harmful to your blood and kidneys. This happens even though the amount of methotrexate in your blood stays the same.
Methotrexate's labeled portfolio outnumbers Celecoxib
SPL source-record counts only. This page's band is moderate · classes on file: Celecoxib (COX-2 Selective NSAID); Methotrexate (Disease-Modifying Antirheumatic Drug (DMARD)).
0 major · 3 moderate · 16 minor · 19 total
- Other moderate peers for Celecoxib
- Diflunisal
- Heparin
0 major · 12 moderate · 26 minor · 38 total
- Other moderate peers for Methotrexate
- Diflunisal
- Indomethacin
- Mefenamic Acid
- Meloxicam
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.