Torsemide and Lithium Interaction
Drug interaction information between Torsemide and Lithium.
Torsemide and Lithium have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Torsemide and Lithium. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This water pill makes it harder for your kidneys to remove lithium from your body. This can cause lithium to build up to toxic levels.
FDA Label Information
( 7.4 ) Lithium: Risk of lithium toxicity ( 7.5 ) Renin-angiotensin inhibitors: Increased risk of hypotension and renal impairment. 7.5 Lithium Like other diuretics, torsemide reduces the renal clearance of lithium, inducing a high risk of lithium toxicity. Monitor lithium levels periodically when torsemide is coadministered.
Torsemide Also Interacts With
- Celecoxib minor
- Warfarin minor
- Fluconazole minor
- Rifampin minor
- Amiodarone minor
Lithium Also Interacts With
- Amlodipine/Benazepril major
- Risperidone major
- Amiloride moderate
- Amiodarone moderate
- Amlodipine/Valsartan moderate
Frequently Asked Questions
What SPL severity band is on file for Torsemide + Lithium?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Lithium has 90 labeled pairs on file vs Torsemide's 11. In the moderate band specifically: Torsemide has 1; Lithium has 23 (also Amiloride, Amiodarone, Amlodipine/Valsartan, Azilsartan).
What mechanism field is on file for Torsemide and Lithium?
This water pill makes it harder for your kidneys to remove lithium from your body. This can cause lithium to build up to toxic levels.
Lithium carries more major-labeled pairs than Torsemide
SPL source-record counts only. This page's band is moderate · classes on file: Torsemide (Loop Diuretic); Lithium (Mood Stabilizer).
Lithium has 2 major-labeled pairs vs Torsemide's 0. This page itself is in the moderate band, not the major band.
0 major · 1 moderate · 10 minor · 11 total
Torsemide has no other moderate-band peer in this dataset besides Lithium.
2 major · 23 moderate · 65 minor · 90 total
- Other moderate peers for Lithium
- Amiloride
- Amiodarone
- Amlodipine/Valsartan
- Azilsartan
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.