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What the FDA labels say about taking them together

Fluconazole and torsemide

Torsemide's FDA label of May 8, 2024 names fluconazole in its drug interactions section; the fluconazole labels PlainMeds reads (2) do not name torsemide. The torsemide label: “Concomitant use of CYP2C9 inhibitors can decrease torsemide clearance and increase torsemide plasma concentrations.”

Check it at the source: the fluconazole FDA label on DailyMed (effective April 7, 2026, Zydus Pharmaceuticals (USA) Inc.); the torsemide FDA label on DailyMed (effective May 8, 2024, Aurobindo Pharma Limited).

What does the fluconazole label say about torsemide?

Fluconazole's label (effective April 7, 2026) and its 1 other brand-application label do not name torsemide in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (fluconazole), Zydus Pharmaceuticals (USA) Inc., effective April 7, 2026 (SPL set d1364455-1537-46d4-b093-38cca3be778f), via openFDA; the full label on DailyMed

What does the torsemide label say about fluconazole?

Torsemide label, drug interactions

Concomitant use of CYP2C9 inhibitors (e.g., amiodarone, fluconazole, miconazole, oxandrolone) can decrease torsemide clearance and increase torsemide plasma concentrations.

Source: FDA drug label (Torsemide), Aurobindo Pharma Limited, effective May 8, 2024 (SPL set 55e88727-864e-4313-860c-31a6ca45168f), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

41Fluconazole generic labelers
20Torsemide generic labelers
FluconazoleTorsemide
Labeled forFungal infections, Urinary tract infectionsHigh blood pressure, Heart failure
Boxed warningNoNo
Pharmacy cost (NADAC)$0.380 per tablet 200 mg tablet$0.0636 per tablet 20 mg tablet
Shortage nowNo current entryNo current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?