Torsemide and Fluconazole Interaction
Drug interaction information between Torsemide and Fluconazole.
Torsemide and Fluconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Torsemide and Fluconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fluconazole blocks the enzyme that breaks down torsemide. This causes the drug to build up in your body.
FDA Label Information
Concomitant use of CYP2C9 inhibitors (e.g., amiodarone, fluconazole, miconazole, oxandrolone) can decrease torsemide clearance and increase torsemide plasma concentrations.
Torsemide Also Interacts With
- Lithium moderate
- Celecoxib minor
- Warfarin minor
- Rifampin minor
- Amiodarone minor
Fluconazole Also Interacts With
- Pimozide major
- Clarithromycin major
- Eplerenone major
- Atorvastatin moderate
- Simvastatin moderate
Frequently Asked Questions
What SPL severity band is on file for Torsemide + Fluconazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluconazole has 67 labeled pairs on file vs Torsemide's 11. In the minor band specifically: Torsemide has 10 (also Celecoxib, Warfarin, Rifampin, Amiodarone); Fluconazole has 57 (also Amlodipine, Losartan, Hydrochlorothiazide, Meloxicam).
What mechanism field is on file for Torsemide and Fluconazole?
Fluconazole blocks the enzyme that breaks down torsemide. This causes the drug to build up in your body.
Fluconazole carries more major-labeled pairs than Torsemide
SPL source-record counts only. This page's band is minor · classes on file: Torsemide (Loop Diuretic); Fluconazole (Azole Antifungal).
Fluconazole has 3 major-labeled pairs vs Torsemide's 0. This page itself is in the minor band, not the major band.
0 major · 1 moderate · 10 minor · 11 total
- Other minor peers for Torsemide
- Celecoxib
- Warfarin
- Rifampin
- Amiodarone
3 major · 7 moderate · 57 minor · 67 total
- Other minor peers for Fluconazole
- Amlodipine
- Losartan
- Hydrochlorothiazide
- Meloxicam
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.