Celecoxib and Furosemide Interaction
Drug interaction information between Celecoxib and Furosemide.
Celecoxib and Furosemide have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Celecoxib and Furosemide. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This pain medicine can reduce the ability of your water pill to remove salt and extra fluid from your body.
FDA Label Information
Diuretics Clinical Impact: Clinical studies, as well as post-marketing observations, showed that NSAIDs reduced the natriuretic effect of loop diuretics (e.g., furosemide) and thiazide diuretics in some patients. ( 7 ) Diuretics : NSAIDs can reduce natriuretic effect of furosemide and thiazide diuretics.
Celecoxib Also Interacts With
- Methotrexate moderate
- Diflunisal moderate
- Heparin moderate
- Meloxicam minor
- Aspirin minor
Furosemide Also Interacts With
- Dutasteride major
- Dutasteride/Tamsulosin major
- Tamsulosin major
- Cyclosporine moderate
- Lithium moderate
Frequently Asked Questions
What SPL severity band is on file for Celecoxib + Furosemide?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Furosemide has 36 labeled pairs on file vs Celecoxib's 19. In the minor band specifically: Celecoxib has 16 (also Meloxicam, Aspirin, Propranolol, Diclofenac); Furosemide has 29 (also Methotrexate, Norepinephrine, Ethacrynic Acid, Indomethacin).
What mechanism field is on file for Celecoxib and Furosemide?
This pain medicine can reduce the ability of your water pill to remove salt and extra fluid from your body.
Furosemide carries more major-labeled pairs than Celecoxib
SPL source-record counts only. This page's band is minor · classes on file: Celecoxib (COX-2 Selective NSAID); Furosemide (Loop Diuretic).
Furosemide has 3 major-labeled pairs vs Celecoxib's 0. This page itself is in the minor band, not the major band.
0 major · 3 moderate · 16 minor · 19 total
- Other minor peers for Celecoxib
- Meloxicam
- Aspirin
- Propranolol
- Diclofenac
3 major · 4 moderate · 29 minor · 36 total
- Other minor peers for Furosemide
- Methotrexate
- Norepinephrine
- Ethacrynic Acid
- Indomethacin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.