Tolterodine and Furosemide Interaction
Drug interaction information between Tolterodine and Furosemide.
Tolterodine and Furosemide have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Tolterodine and Furosemide. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
There is no known interaction between these drugs, and they do not cause any harmful effects on the heart when taken together.
FDA Label Information
Diuretics Coadministration of tolterodine immediate release up to 8 mg (4 mg bid) for up to 12 weeks with diuretic agents, such as indapamide, hydrochlorothiazide, triamterene, bendroflumethiazide, chlorothiazide, methylchlorothiazide, or furosemide, did not cause any adverse electrocardiographic (ECG) effects.
Tolterodine Also Interacts With
- Clarithromycin moderate
- Omeprazole minor
- Hydrochlorothiazide minor
- Fluoxetine minor
- Estradiol minor
Furosemide Also Interacts With
- Dutasteride major
- Dutasteride/Tamsulosin major
- Tamsulosin major
- Cyclosporine moderate
- Lithium moderate
Frequently Asked Questions
What SPL severity band is on file for Tolterodine + Furosemide?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Furosemide has 36 labeled pairs on file vs Tolterodine's 15. In the minor band specifically: Tolterodine has 14 (also Omeprazole, Hydrochlorothiazide, Fluoxetine, Estradiol); Furosemide has 29 (also Methotrexate, Norepinephrine, Ethacrynic Acid, Indomethacin).
What mechanism field is on file for Tolterodine and Furosemide?
There is no known interaction between these drugs, and they do not cause any harmful effects on the heart when taken together.
Furosemide carries more major-labeled pairs than Tolterodine
SPL source-record counts only. This page's band is minor · classes on file: Tolterodine (Anticholinergic (Overactive Bladder)); Furosemide (Loop Diuretic).
Furosemide has 3 major-labeled pairs vs Tolterodine's 0. This page itself is in the minor band, not the major band.
0 major · 1 moderate · 14 minor · 15 total
- Other minor peers for Tolterodine
- Omeprazole
- Hydrochlorothiazide
- Fluoxetine
- Estradiol
3 major · 4 moderate · 29 minor · 36 total
- Other minor peers for Furosemide
- Methotrexate
- Norepinephrine
- Ethacrynic Acid
- Indomethacin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.