Tolterodine and Estradiol Interaction
Drug interaction information between Tolterodine and Estradiol.
Tolterodine and Estradiol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Tolterodine and Estradiol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Tolterodine does not interfere with how birth control medications work or change the amount of hormone in your body.
FDA Label Information
7.3 Other Interactions No clinically relevant interactions have been observed when tolterodine was co-administered with warfarin, with a combined oral contraceptive drug containing ethinyl estradiol and levonorgestrel, or with diuretics [see Clinical Pharmacology (12.3) ] . Oral Contraceptives Tolterodine immediate release 4 mg (2 mg bid) had no effect on the pharmacokinetics of an oral contraceptive (ethinyl estradiol 30 µg/levonorgestrel 150 µg) as evidenced by the monitoring of ethinyl estradiol and levonorgestrel over a 2-month period in healthy female volunteers.
Tolterodine Also Interacts With
- Clarithromycin moderate
- Omeprazole minor
- Hydrochlorothiazide minor
- Fluoxetine minor
- Furosemide minor
Estradiol Also Interacts With
- Drospirenone/Ethinyl Estradiol major
- Glecaprevir/Pibrentasvir moderate
- Etonogestrel moderate
- Tacrolimus Topical moderate
- Rosuvastatin minor
Frequently Asked Questions
What SPL severity band is on file for Tolterodine + Estradiol?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Estradiol has 54 labeled pairs on file vs Tolterodine's 15. In the minor band specifically: Tolterodine has 14 (also Omeprazole, Hydrochlorothiazide, Fluoxetine, Furosemide); Estradiol has 50 (also Rosuvastatin, Lamotrigine, Topiramate, Tizanidine).
What mechanism field is on file for Tolterodine and Estradiol?
Tolterodine does not interfere with how birth control medications work or change the amount of hormone in your body.
Estradiol carries more major-labeled pairs than Tolterodine
SPL source-record counts only. This page's band is minor · classes on file: Tolterodine (Anticholinergic (Overactive Bladder)); Estradiol (Estrogen Hormone).
Estradiol has 1 major-labeled pair vs Tolterodine's 0. This page itself is in the minor band, not the major band.
0 major · 1 moderate · 14 minor · 15 total
- Other minor peers for Tolterodine
- Omeprazole
- Hydrochlorothiazide
- Fluoxetine
- Furosemide
1 major · 3 moderate · 50 minor · 54 total
- Other minor peers for Estradiol
- Rosuvastatin
- Lamotrigine
- Topiramate
- Tizanidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.