Tolterodine and Hydrochlorothiazide Interaction
Drug interaction information between Tolterodine and Hydrochlorothiazide.
Tolterodine and Hydrochlorothiazide have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Tolterodine and Hydrochlorothiazide. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Studies show that taking these two drugs together does not cause any dangerous changes to your heart rhythm.
FDA Label Information
Diuretics Coadministration of tolterodine immediate release up to 8 mg (4 mg bid) for up to 12 weeks with diuretic agents, such as indapamide, hydrochlorothiazide, triamterene, bendroflumethiazide, chlorothiazide, methylchlorothiazide, or furosemide, did not cause any adverse electrocardiographic (ECG) effects.
Tolterodine Also Interacts With
- Clarithromycin moderate
- Omeprazole minor
- Fluoxetine minor
- Furosemide minor
- Estradiol minor
Hydrochlorothiazide Also Interacts With
- Aliskiren major
- Hydrochlorothiazide/Triamterene major
- Lisinopril major
- Olmesartan moderate
- Losartan minor
Frequently Asked Questions
What SPL severity band is on file for Tolterodine + Hydrochlorothiazide?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Hydrochlorothiazide has 31 labeled pairs on file vs Tolterodine's 15. In the minor band specifically: Tolterodine has 14 (also Omeprazole, Fluoxetine, Furosemide, Estradiol); Hydrochlorothiazide has 27 (also Losartan, Spironolactone, Propranolol, Lithium).
What mechanism field is on file for Tolterodine and Hydrochlorothiazide?
Studies show that taking these two drugs together does not cause any dangerous changes to your heart rhythm.
Hydrochlorothiazide carries more major-labeled pairs than Tolterodine
SPL source-record counts only. This page's band is minor · classes on file: Tolterodine (Anticholinergic (Overactive Bladder)); Hydrochlorothiazide (Thiazide Diuretic).
Hydrochlorothiazide has 3 major-labeled pairs vs Tolterodine's 0. This page itself is in the minor band, not the major band.
0 major · 1 moderate · 14 minor · 15 total
- Other minor peers for Tolterodine
- Omeprazole
- Fluoxetine
- Furosemide
- Estradiol
3 major · 1 moderate · 27 minor · 31 total
- Other minor peers for Hydrochlorothiazide
- Losartan
- Spironolactone
- Propranolol
- Lithium
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.