Tolterodine and Omeprazole Interaction
Drug interaction information between Tolterodine and Omeprazole.
Tolterodine and Omeprazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Tolterodine and Omeprazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Tolterodine does not change how the body processes omeprazole, meaning they do not have a meaningful interaction.
FDA Label Information
7.4 Other Drugs Metabolized by Cytochrome P450 Isoenzymes In vivo drug-interaction data show that tolterodine immediate release does not result in clinically relevant inhibition of CYP1A2, 2D6, 2C9, 2C19, or 3A4 as evidenced by lack of influence on the marker drugs caffeine, debrisoquine, S-warfarin, and omeprazole [see Clinical Pharmacology (12.3) ] . In vivo drug-interaction data show that tolterodine immediate release does not result in clinically relevant inhibition of CYP1A2, 2D6, 2C9, 2C19, or 3A4 as evidenced by lack of influence on the marker drugs caffeine, debrisoquine,...
Tolterodine Also Interacts With
- Clarithromycin moderate
- Hydrochlorothiazide minor
- Fluoxetine minor
- Furosemide minor
- Estradiol minor
Omeprazole Also Interacts With
- Theophylline major
- Clarithromycin moderate
- Clopidogrel moderate
- Darunavir moderate
- Tacrolimus Topical moderate
Frequently Asked Questions
What SPL severity band is on file for Tolterodine + Omeprazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Omeprazole has 27 labeled pairs on file vs Tolterodine's 15. In the minor band specifically: Tolterodine has 14 (also Hydrochlorothiazide, Fluoxetine, Furosemide, Estradiol); Omeprazole has 22 (also Aripiprazole, Atomoxetine, Brexpiprazole, Carbamazepine).
What mechanism field is on file for Tolterodine and Omeprazole?
Tolterodine does not change how the body processes omeprazole, meaning they do not have a meaningful interaction.
Omeprazole carries more major-labeled pairs than Tolterodine
SPL source-record counts only. This page's band is minor · classes on file: Tolterodine (Anticholinergic (Overactive Bladder)); Omeprazole (Proton Pump Inhibitor (PPI)).
Omeprazole has 1 major-labeled pair vs Tolterodine's 0. This page itself is in the minor band, not the major band.
0 major · 1 moderate · 14 minor · 15 total
- Other minor peers for Tolterodine
- Hydrochlorothiazide
- Fluoxetine
- Furosemide
- Estradiol
1 major · 4 moderate · 22 minor · 27 total
- Other minor peers for Omeprazole
- Aripiprazole
- Atomoxetine
- Brexpiprazole
- Carbamazepine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.