cimetidine vs tiagabine
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Side-by-side comparison of cimetidine and tiagabine. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Interaction of Tiagabine Hydrochloride with Other Drugs: Cimetidine: Co-administration of cimetidine (800 mg/day) to patients taking tiagabine chronically had no effect on tiagabine pharmacokinetics.
Tagamet
Gabitril
Cimetidine (Tagamet) reduces stomach acid. It is used to treat ulcers, heartburn, and other conditions where too much acid is produced.
Tiagabine is a medicine used with other medicines to treat partial seizures. It helps to control seizures by affecting certain chemicals in the brain.
Cimetidine treats active duodenal ulcers for short periods. It can also be used long-term at a lower dose to prevent ulcers from returning. This medicine also treats active benign gastric ulcers for a short time. Additionally, it can help with erosive gastroesophageal reflux disease (GERD), which damages the esophagus.
Tiagabine is used to treat partial seizures in adults and children 12 years and older. It is used along with other seizure medicines. Partial seizures affect only one part of the brain.
Cimetidine is an H2 receptor antagonist. This means it blocks histamine from attaching to certain cells in your stomach. By blocking histamine, cimetidine reduces the amount of acid your stomach makes.
Tiagabine works by increasing the amount of a chemical called GABA in the brain. GABA helps to calm the brain and reduce seizures. Tiagabine blocks the reuptake of GABA, which means more GABA is available in the brain.
- • Headache
- • Dizziness
- • Diarrhea
- • Dizziness
- • Lack of energy
- • Sleepiness
- • Nausea
- • Nervousness or irritability
- Chronic Kidney Disease 1,264
- Acute Kidney Injury 710
- Renal Failure 694
- Nausea 681
- Fatigue 598
- Encephalopathy 16
- Myoclonus 14
- Dizziness 6
- Feeling Abnormal 5
- Seizure 5
Reversible confusional states (like mental confusion, agitation, or hallucinations) have been reported, mostly in severely ill patients. These usually appear within 2-3 days of starting treatment and clear up within 3-4 days of stopping the drug.
This medicine may cause serious side effects. Tell your doctor right away if you have any changes in mood or behavior, or any suicidal thoughts.
Tell your doctor if you are pregnant or plan to become pregnant. The effects of cimetidine during pregnancy are not fully known. Talk to your doctor about the risks and benefits of taking cimetidine while breastfeeding.
Tell your doctor if you are pregnant or plan to become pregnant. It is not known if tiagabine will harm your unborn baby. Talk to your doctor about the risks and benefits of taking tiagabine during pregnancy.
Also Compare, Nearby Drugs
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How to Read This cimetidine vs tiagabine Comparison
cimetidine is classified in the H2 Receptor Antagonist drug class, while tiagabine sits within the Anticonvulsant (GABA Reuptake Inhibitor) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are split between OTC and prescription status, which affects access and supervision.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, cimetidine has 3,947 submissions while tiagabine has 46. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to cimetidine does not affect the way the body processes or removes tiagabine.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for cimetidine or tiagabine.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.