Gentamicin and Digoxin Interaction
Drug interaction information between Gentamicin and Digoxin.
Gentamicin and Digoxin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Gentamicin and Digoxin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Gentamicin can significantly increase the amount of digoxin in your blood, sometimes doubling it or more. This happens because the antibiotic affects how your body clears the heart medicine.
FDA Label Information
Captopril 58% 39% Clarithromycin NA 70% Dronedarone NA 150% Gentamicin 129-212% NA Erythromycin 100% NA Itraconazole 80% NA Lapatinib NA 180% Propafenone NA 60-270% Quinidine 100% NA Ranolazine 50% NA Ritonavir NA 86% Telaprevir 50% 85% Tetracycline 100% NA Verapamil 50-75% NA Digoxin concentrations increased less than 50% Atorvastatin 22% 15% Carvedilol 16% 14% Measure serum digoxin concentrations before initiating concomitant drugs.
Gentamicin Also Interacts With
- Cidofovir major
- Bictegravir/Emtricitabine/Tenofovir minor
- Emtricitabine/Tenofovir minor
- Perindopril minor
- Piperacillin/Tazobactam minor
Digoxin Also Interacts With
- Nicardipine major
- Posaconazole major
- Sotalol moderate
- Dofetilide moderate
- Ivabradine moderate
Frequently Asked Questions
What SPL severity band is on file for Gentamicin + Digoxin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Digoxin has 120 labeled pairs on file vs Gentamicin's 7. In the minor band specifically: Gentamicin has 6 (also Bictegravir, Emtricitabine/Tenofovir, Perindopril, Piperacillin/Tazobactam); Digoxin has 105 (also Metformin, Omeprazole, Ibuprofen, Diclofenac).
What mechanism field is on file for Gentamicin and Digoxin?
Gentamicin can significantly increase the amount of digoxin in your blood, sometimes doubling it or more. This happens because the antibiotic affects how your body clears the heart medicine.
Digoxin carries more major-labeled pairs than Gentamicin
SPL source-record counts only. This page's band is minor · classes on file: Gentamicin (Aminoglycoside Antibiotic); Digoxin (Cardiac Glycoside).
Digoxin has 2 major-labeled pairs vs Gentamicin's 1. This page itself is in the minor band, not the major band.
1 major · 0 moderate · 6 minor · 7 total
- Other minor peers for Gentamicin
- Bictegravir
- Emtricitabine/Tenofovir
- Perindopril
- Piperacillin/Tazobactam
2 major · 13 moderate · 105 minor · 120 total
- Other minor peers for Digoxin
- Metformin
- Omeprazole
- Ibuprofen
- Diclofenac
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.