Gentamicin and Perindopril Interaction
Drug interaction information between Gentamicin and Perindopril.
Gentamicin and Perindopril have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Gentamicin and Perindopril. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Research in animals suggests these two drugs might interact, although the exact way they affect humans is not yet fully understood.
What To Do
Your doctor should monitor you closely for any unusual side effects if you are prescribed both medications.
FDA Label Information
7.6 Gentamicin Animal data have suggested the possibility of interaction between perindopril and gentamicin.
Gentamicin Also Interacts With
- Cidofovir major
- Bictegravir/Emtricitabine/Tenofovir minor
- Digoxin minor
- Emtricitabine/Tenofovir minor
- Piperacillin/Tazobactam minor
Perindopril Also Interacts With
- Aliskiren major
- Spironolactone moderate
- Cyclosporine moderate
- Amiloride moderate
- Indomethacin moderate
Frequently Asked Questions
Can I take Gentamicin and Perindopril together?
This is a minor interaction. Your doctor should monitor you closely for any unusual side effects if you are prescribed both medications.
How serious is the interaction between Gentamicin and Perindopril?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Gentamicin and Perindopril interact?
Research in animals suggests these two drugs might interact, although the exact way they affect humans is not yet fully understood.
Understanding the Gentamicin and Perindopril Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Gentamicin belongs to the Aminoglycoside Antibiotic class and Perindopril belongs to the ACE Inhibitor class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Research in animals suggests these two drugs might interact, although the exact way they affect humans is not yet fully understood. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Gentamicin has 7 total documented interactions on file in this dataset, and Perindopril has 9. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor should monitor you closely for any unusual side effects if you are prescribed both medications. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Gentamicin or Perindopril based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.