Gentamicin and Cidofovir Interaction
Drug interaction information between Gentamicin and Cidofovir.
Gentamicin and Cidofovir have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Gentamicin and Cidofovir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These medications are both known to be toxic to the kidneys. Using them together can cause severe kidney problems.
FDA Label Information
Nephrotoxic agents Concomitant administration of cidofovir injection and agents with nephrotoxic potential [e.g., intravenous aminoglycosides (e.g., tobramycin, gentamicin, and amikacin), amphotericin B, foscarnet, intravenous pentamidine, vancomycin, and nonsteroidal anti-inflammatory agents] is contraindicated.
Gentamicin Also Interacts With
- Bictegravir/Emtricitabine/Tenofovir minor
- Digoxin minor
- Emtricitabine/Tenofovir minor
- Perindopril minor
- Piperacillin/Tazobactam minor
Cidofovir Also Interacts With
- Vancomycin major
- Tobramycin major
- Amikacin major
- Amphotericin B major
- Furosemide minor
Frequently Asked Questions
What SPL severity band is on file for Gentamicin + Cidofovir?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cidofovir has 16 labeled pairs on file vs Gentamicin's 7. In the major band specifically: Gentamicin has 1; Cidofovir has 5 (also Vancomycin, Tobramycin, Amikacin, Amphotericin B).
What mechanism field is on file for Gentamicin and Cidofovir?
These medications are both known to be toxic to the kidneys. Using them together can cause severe kidney problems.
Cidofovir carries more major-labeled pairs than Gentamicin
SPL source-record counts only. This page's band is major · classes on file: Gentamicin (Aminoglycoside Antibiotic); Cidofovir (Antiviral (Nucleotide Analog)).
Cidofovir has 5 major-labeled pairs vs Gentamicin's 1.
1 major · 0 moderate · 6 minor · 7 total
Gentamicin has no other major-band peer in this dataset besides Cidofovir.
5 major · 0 moderate · 11 minor · 16 total
- Other major peers for Cidofovir
- Vancomycin
- Tobramycin
- Amikacin
- Amphotericin B
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.