Gentamicin and Bictegravir Interaction
Drug interaction information between Gentamicin and Bictegravir.
Gentamicin and Bictegravir have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Gentamicin and Bictegravir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs are removed from the body through the same pathway in the kidneys. Taking them together may cause the drugs to build up in your system.
FDA Label Information
Some examples of drugs that are eliminated by active tubular secretion include, but are not limited to, acyclovir, cidofovir, ganciclovir, valacyclovir, valganciclovir, aminoglycosides (e.g., gentamicin), and high-dose or multiple NSAIDs [see Warnings and Precautions (5.4) ] .
Gentamicin Also Interacts With
- Cidofovir major
- Digoxin minor
- Emtricitabine/Tenofovir minor
- Perindopril minor
- Piperacillin/Tazobactam minor
Bictegravir Also Interacts With
- Rifampin major
- Dofetilide major
- Metformin moderate
- Sertraline minor
- Estradiol minor
Frequently Asked Questions
What SPL severity band is on file for Gentamicin + Bictegravir/Emtricitabine/Tenofovir?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Bictegravir has 19 labeled pairs on file vs Gentamicin's 7. In the minor band specifically: Gentamicin has 6 (also Digoxin, Emtricitabine/Tenofovir, Perindopril, Piperacillin/Tazobactam); Bictegravir has 16 (also Sertraline, Estradiol, Valacyclovir, Acyclovir).
What mechanism field is on file for Gentamicin and Bictegravir/Emtricitabine/Tenofovir?
Both drugs are removed from the body through the same pathway in the kidneys. Taking them together may cause the drugs to build up in your system.
Bictegravir carries more major-labeled pairs than Gentamicin
SPL source-record counts only. This page's band is minor · classes on file: Gentamicin (Aminoglycoside Antibiotic); Bictegravir (Integrase Inhibitor / NRTI Combination).
Bictegravir has 2 major-labeled pairs vs Gentamicin's 1. This page itself is in the minor band, not the major band.
1 major · 0 moderate · 6 minor · 7 total
- Other minor peers for Gentamicin
- Digoxin
- Emtricitabine/Tenofovir
- Perindopril
- Piperacillin/Tazobactam
2 major · 1 moderate · 16 minor · 19 total
- Other minor peers for Bictegravir
- Sertraline
- Estradiol
- Valacyclovir
- Acyclovir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.