tadalafil vs warfarin
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Side-by-side comparison of tadalafil and warfarin. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Warfarin) — Tadalafil had no significant effect on exposure (AUC) to S-warfarin or R-warfarin, nor did tadalafil affect changes in prothrombin time induced by warfarin.
Tadalafil (Cialis) is a medicine that helps men with erectile dysfunction (ED) or enlarged prostate (BPH). It belongs to a class of drugs called PDE5 inhibitors.
Warfarin is a medicine that helps prevent blood clots. It is used to treat and prevent dangerous clots from forming in your body.
This medicine can help men who have trouble getting or keeping an erection (ED). It can also treat the symptoms of an enlarged prostate, also known as benign prostatic hyperplasia (BPH). BPH can cause difficulty with urination.
Warfarin is used to prevent and treat blood clots in your veins and lungs. It can also prevent clots if you have atrial fibrillation (irregular heartbeat) or a replacement heart valve. After a heart attack, it can lower the risk of death, another heart attack, or a stroke.
Tadalafil works by relaxing the muscles in the penis and prostate. This increases blood flow to these areas. For BPH, it relaxes muscles in the prostate and bladder, which can improve urinary symptoms.
Warfarin works by blocking your body's use of vitamin K. Vitamin K is needed to make blood clotting factors. By blocking vitamin K, warfarin makes your blood less likely to clot.
- • Headache
- • Upset stomach
- • Back pain
- • Muscle aches
- • Nasal congestion
- • Bleeding from any tissue or organ
- Dyspnoea 11,663
- Headache 10,690
- Diarrhoea 7,799
- Nausea 6,498
- Death 5,899
- International Normalised Ratio Increased 10,276
- Dyspnoea 8,408
- Drug Interaction 6,288
- Fatigue 6,143
- Nausea 5,921
If you have chest pain, tell your doctor. If you need nitrates for a heart problem, wait 48 hours after taking tadalafil before taking nitrates. If you get an erection that lasts more than 4 hours, get medical help right away. If you have sudden vision loss in one or both eyes, stop taking this medicine and get medical help right away. If you have a sudden decrease or loss of hearing, stop taking this medicine and get medical help right away.
Warfarin can cause major or fatal bleeding. You must have your blood tested regularly (INR) while taking warfarin. Many things, like other medicines and diet changes, can affect your INR. Tell your doctor about any bleeding and follow their instructions to prevent bleeding.
This medicine is not for use in women. It is not known if this medicine will harm an unborn baby. It is also not known if this medicine passes into breast milk.
Warfarin can harm your unborn baby, especially during the first three months of pregnancy. Do not take warfarin if you are pregnant, unless you have a mechanical heart valve and your doctor says the benefits outweigh the risks. Talk to your doctor if you are breastfeeding, and watch your baby for bruising or bleeding.
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How to Read This tadalafil vs warfarin Comparison
tadalafil is classified in the PDE5 Inhibitor drug class, while warfarin sits within the Vitamin K Antagonist (Anticoagulant) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, tadalafil has 42,549 submissions while warfarin has 37,036. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to tadalafil does not change the amount of warfarin in the body or interfere with its ability to thin the blood.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for tadalafil or warfarin.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.