Sumatriptan and Norepinephrine Interaction
Drug interaction information between Sumatriptan and Norepinephrine.
Sumatriptan and Norepinephrine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Sumatriptan and Norepinephrine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs can increase serotonin levels in the body, which may lead to a serious reaction called serotonin syndrome.
FDA Label Information
7.4 Selective Serotonin Reuptake Inhibitors /Serotonin Norepinephrine Reuptake Inhibitors and Serotonin Syndrome Cases of serotonin syndrome have been reported during coadministration of triptans and SSRIs, SNRIs, TCAs, and MAO inhibitors [see Warnings and Precautions (5.7)].
Sumatriptan Also Interacts With
- Escitalopram minor
- Fluvoxamine minor
- Sertraline minor
Norepinephrine Also Interacts With
- Tranylcypromine major
- Carbidopa/Levodopa moderate
- Clopidogrel moderate
- Deutetrabenazine moderate
- Digoxin moderate
Frequently Asked Questions
What SPL severity band is on file for Sumatriptan + Norepinephrine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Norepinephrine has 50 labeled pairs on file vs Sumatriptan's 4. In the minor band specifically: Sumatriptan has 4 (also Escitalopram, Fluvoxamine, Sertraline); Norepinephrine has 42 (also Amitriptyline, Linezolid, Nortriptyline, Desipramine).
What mechanism field is on file for Sumatriptan and Norepinephrine?
Both drugs can increase serotonin levels in the body, which may lead to a serious reaction called serotonin syndrome.
Norepinephrine carries more major-labeled pairs than Sumatriptan
SPL source-record counts only. This page's band is minor · classes on file: Sumatriptan (Triptan (Serotonin 5-HT1 Agonist)); Norepinephrine (Vasopressor (Alpha-1 Agonist)).
Norepinephrine has 1 major-labeled pair vs Sumatriptan's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 4 minor · 4 total
- Other minor peers for Sumatriptan
- Escitalopram
- Fluvoxamine
- Sertraline
1 major · 7 moderate · 42 minor · 50 total
- Other minor peers for Norepinephrine
- Amitriptyline
- Linezolid
- Nortriptyline
- Desipramine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.