Sumatriptan and Escitalopram Interaction
Drug interaction information between Sumatriptan and Escitalopram.
Sumatriptan and Escitalopram have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Sumatriptan and Escitalopram. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Combining these medicines can lead to physical issues like weakness and poor coordination by affecting serotonin in the body.
FDA Label Information
Sumatriptan Clinical Impact: There have been postmarketing reports describing patients with weakness, hyperreflexia, and incoordination following the use of an SSRI and sumatriptan. Intervention: If concomitant treatment with sumatriptan and an SSRI is clinically warranted, appropriate observation of the patient is advised [ see Warnings and Precautions (5.2) ].
Sumatriptan Also Interacts With
- Norepinephrine minor
- Fluvoxamine minor
- Sertraline minor
Escitalopram Also Interacts With
- Citalopram major
- Linezolid major
- Pimozide major
- Aspirin moderate
- Warfarin moderate
Frequently Asked Questions
What SPL severity band is on file for Sumatriptan + Escitalopram?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Escitalopram has 12 labeled pairs on file vs Sumatriptan's 4. In the minor band specifically: Sumatriptan has 4 (also Norepinephrine, Fluvoxamine, Sertraline); Escitalopram has 7 (also Buspirone, Carbamazepine, Lithium, Desipramine).
What mechanism field is on file for Sumatriptan and Escitalopram?
Combining these medicines can lead to physical issues like weakness and poor coordination by affecting serotonin in the body.
Escitalopram carries more major-labeled pairs than Sumatriptan
SPL source-record counts only. This page's band is minor · classes on file: Sumatriptan (Triptan (Serotonin 5-HT1 Agonist)); Escitalopram (Selective Serotonin Reuptake Inhibitor (SSRI)).
Escitalopram has 3 major-labeled pairs vs Sumatriptan's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 4 minor · 4 total
- Other minor peers for Sumatriptan
- Norepinephrine
- Fluvoxamine
- Sertraline
3 major · 2 moderate · 7 minor · 12 total
- Other minor peers for Escitalopram
- Buspirone
- Carbamazepine
- Lithium
- Desipramine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.