Sumatriptan and Sertraline Interaction
Drug interaction information between Sumatriptan and Sertraline.
Sumatriptan and Sertraline have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Sumatriptan and Sertraline. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Combining these drugs can rarely cause a reaction that leads to muscle weakness, overactive reflexes, or loss of coordination.
FDA Label Information
Sumatriptan –There have been rare postmarketing reports describing patients with weakness, hyperreflexia, and incoordination following the use of a selective serotonin reuptake inhibitor (SSRI) and sumatriptan. If concomitant treatment with sumatriptan and an SSRI (e.g., citalopram, fluoxetine, fluvoxamine, paroxetine, sertraline) is clinically warranted, appropriate observation of the patient is advised.
Sumatriptan Also Interacts With
- Norepinephrine minor
- Escitalopram minor
- Fluvoxamine minor
Sertraline Also Interacts With
- Clonazepam major
- Aspirin moderate
- Phenelzine moderate
- Fluoxetine minor
- Citalopram minor
Frequently Asked Questions
What SPL severity band is on file for Sumatriptan + Sertraline?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Sertraline has 34 labeled pairs on file vs Sumatriptan's 4. In the minor band specifically: Sumatriptan has 4 (also Norepinephrine, Escitalopram, Fluvoxamine); Sertraline has 31 (also Fluoxetine, Citalopram, Paroxetine, Atenolol).
What mechanism field is on file for Sumatriptan and Sertraline?
Combining these drugs can rarely cause a reaction that leads to muscle weakness, overactive reflexes, or loss of coordination.
Sertraline carries more major-labeled pairs than Sumatriptan
SPL source-record counts only. This page's band is minor · classes on file: Sumatriptan (Triptan (Serotonin 5-HT1 Agonist)); Sertraline (Selective Serotonin Reuptake Inhibitor (SSRI)).
Sertraline has 1 major-labeled pair vs Sumatriptan's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 4 minor · 4 total
- Other minor peers for Sumatriptan
- Norepinephrine
- Escitalopram
- Fluvoxamine
1 major · 2 moderate · 31 minor · 34 total
- Other minor peers for Sertraline
- Fluoxetine
- Citalopram
- Paroxetine
- Atenolol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.