Selegiline and Dopamine Interaction
Drug interaction information between Selegiline and Dopamine.
Selegiline and Dopamine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Selegiline and Dopamine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This drug prevents the body from breaking down dopamine, which makes the dopamine much more powerful. This can lead to a severe and rapid increase in blood pressure.
FDA Label Information
Examples: isocarboxazid, phenelzine, tranylcypromine, rasagiline, selegiline, linezolid.
Selegiline Also Interacts With
- Desvenlafaxine moderate
- Levomilnacipran moderate
- Mirtazapine moderate
- Paroxetine moderate
- Trazodone moderate
Dopamine Also Interacts With
- Carbidopa/Levodopa moderate
- Deutetrabenazine moderate
- Digoxin moderate
- Tetrabenazine moderate
- Tranylcypromine moderate
Frequently Asked Questions
What SPL severity band is on file for Selegiline + Dopamine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Dopamine has 28 labeled pairs on file vs Selegiline's 9. In the minor band specifically: Selegiline has 3 (also Meperidine, Methylphenidate); Dopamine has 23 (also Amitriptyline, Doxepin, Linezolid, Nortriptyline).
What mechanism field is on file for Selegiline and Dopamine?
This drug prevents the body from breaking down dopamine, which makes the dopamine much more powerful. This can lead to a severe and rapid increase in blood pressure.
Dopamine's labeled portfolio outnumbers Selegiline
SPL source-record counts only. This page's band is minor · classes on file: Selegiline (Selective MAO-B Inhibitor); Dopamine (Inotropic / Vasopressor).
0 major · 6 moderate · 3 minor · 9 total
- Other minor peers for Selegiline
- Meperidine
- Methylphenidate
0 major · 5 moderate · 23 minor · 28 total
- Other minor peers for Dopamine
- Amitriptyline
- Doxepin
- Linezolid
- Nortriptyline
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.