Selegiline and Trazodone Interaction
Drug interaction information between Selegiline and Trazodone.
Selegiline and Trazodone have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Selegiline and Trazodone. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
These medications both raise serotonin levels, and taking them at the same time increases the risk of a toxic reaction.
What To Do
Consult your doctor before combining these drugs to ensure they are safe for you to use together.
FDA Label Information
Examples: isocarboxazid, moclobemide, phenelzine, selegiline, tranylcypromine Other Serotonergic Drugs Clinical Impact: The concomitant use of serotonergic drugs including trazodone and other serotonergic drugs increases the risk of serotonin syndrome.
Selegiline Also Interacts With
- Desvenlafaxine moderate
- Levomilnacipran moderate
- Mirtazapine moderate
- Paroxetine moderate
- Vortioxetine moderate
Trazodone Also Interacts With
- Linezolid major
- Aspirin moderate
- Phenelzine moderate
- Tranylcypromine moderate
- Tramadol minor
Frequently Asked Questions
Can I take Selegiline and Trazodone together?
This is a moderate interaction. Consult your doctor before combining these drugs to ensure they are safe for you to use together.
How serious is the interaction between Selegiline and Trazodone?
This interaction is classified as "moderate" severity by the FDA. Moderate interactions may worsen your condition or change how your medications work.
Why do Selegiline and Trazodone interact?
These medications both raise serotonin levels, and taking them at the same time increases the risk of a toxic reaction.
Understanding the Selegiline and Trazodone Interaction
FDA-approved prescribing information for these two drugs flags their combination as a moderate-severity interaction. Selegiline belongs to the Selective MAO-B Inhibitor class and Trazodone belongs to the Serotonin Antagonist and Reuptake Inhibitor (SARI) class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: These medications both raise serotonin levels, and taking them at the same time increases the risk of a toxic reaction. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Selegiline has 9 total documented interactions on file in this dataset, and Trazodone has 40. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Consult your doctor before combining these drugs to ensure they are safe for you to use together. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Selegiline or Trazodone based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.