What the FDA labels say about taking them together
Selegiline and trazodone
Trazodone's FDA label of January 22, 2026 names selegiline in its drug interactions section; selegiline's label does not name trazodone itself but warns about its class (serotonin reuptake inhibitors).
Check it at the source: the selegiline FDA label on DailyMed (effective August 7, 2024, Rising Pharma Holdings, Inc.); the trazodone FDA label on DailyMed (effective January 22, 2026, Zydus Pharmaceuticals USA Inc.).
What does the selegiline label say about trazodone?
Selegiline's label does not name trazodone itself; it warns about its class (serotonin reuptake inhibitors):
Selegiline label, contraindicationsEMSAM (selegiline transdermal system) is contraindicated with selective serotonin reuptake inhibitors (SSRIs, e.g., fluoxetine, sertraline, and paroxetine); serotonin and norepinephrine reuptake inhibitors (SNRIs, e.g., venlafaxine and duloxetine); the tricyclic antidepressants clomipramine and imipramine, the opiate analgesics meperidine, tramadol, methadone, pentazocine, and propoxyphene; …
Selegiline label, contraindicationsSerotonergic drugs: selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), clomipramine and imipramine, meperidine, tramadol, methadone, pentazocine, and propoxyphene; and the antitussive agent dextromethorphan should not be used with EMSAM because of a risk of serotonin syndrome ( 4 , 5.2 ).
Source: FDA drug label (Selegiline Hydrochloride), Rising Pharma Holdings, Inc., effective August 7, 2024 (SPL set 23c4481f-d150-40c6-addb-b3e454ca914f), via openFDA; the full label on DailyMed
What does the trazodone label say about selegiline?
Trazodone label, drug interactionsExamples; isocarboxazid, moclobemide, phenelzine, selegiline, tranylcypromine
Source: FDA drug label (Trazodone Hydrochloride), Zydus Pharmaceuticals USA Inc., effective January 22, 2026 (SPL set 704aebf9-2fff-4ef3-8323-9ff0d7f0ffd9), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Selegiline | Trazodone | |
|---|---|---|
| Labeled for | Parkinson's disease, Depression | Depression |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.756 per capsule 5 mg capsule | $0.0307 per tablet 50 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once