Dopamine and Amitriptyline Interaction
Drug interaction information between Dopamine and Amitriptyline.
Dopamine and Amitriptyline have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Dopamine and Amitriptyline. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Amitriptyline can make your heart and blood vessels more sensitive to dopamine. This can cause your blood pressure to rise higher than it normally would.
FDA Label Information
Examples: amitriptyline, desipramine, doxepin, imipramine, nortriptyline.
Dopamine Also Interacts With
- Carbidopa/Levodopa moderate
- Deutetrabenazine moderate
- Digoxin moderate
- Tetrabenazine moderate
- Tranylcypromine moderate
Amitriptyline Also Interacts With
- Risperidone major
- Sertraline minor
- Fluoxetine minor
- Paroxetine minor
- Disulfiram minor
Frequently Asked Questions
What SPL severity band is on file for Dopamine + Amitriptyline?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Dopamine has 28 labeled pairs on file vs Amitriptyline's 21. In the minor band specifically: Dopamine has 23 (also Doxepin, Linezolid, Nortriptyline, Imipramine); Amitriptyline has 20 (also Sertraline, Fluoxetine, Paroxetine, Disulfiram).
What mechanism field is on file for Dopamine and Amitriptyline?
Amitriptyline can make your heart and blood vessels more sensitive to dopamine. This can cause your blood pressure to rise higher than it normally would.
Amitriptyline carries more major-labeled pairs than Dopamine
SPL source-record counts only. This page's band is minor · classes on file: Dopamine (Inotropic / Vasopressor); Amitriptyline (Tricyclic Antidepressant (TCA)).
Amitriptyline has 1 major-labeled pair vs Dopamine's 0. This page itself is in the minor band, not the major band.
0 major · 5 moderate · 23 minor · 28 total
- Other minor peers for Dopamine
- Doxepin
- Linezolid
- Nortriptyline
- Imipramine
1 major · 0 moderate · 20 minor · 21 total
- Other minor peers for Amitriptyline
- Sertraline
- Fluoxetine
- Paroxetine
- Disulfiram
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.