Selegiline and Meperidine Interaction
Drug interaction information between Selegiline and Meperidine.
Selegiline and Meperidine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Selegiline and Meperidine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Combining these drugs can cause a severe and dangerous reaction that affects your muscles, temperature, and brain function.
FDA Label Information
Drug Interactions The occurrence of stupor, muscular rigidity, severe agitation, and elevated temperature has been reported in some patients receiving the combination of selegiline and meperidine. This is typical of the interaction of meperidine and MAOIs.
Selegiline Also Interacts With
- Desvenlafaxine moderate
- Levomilnacipran moderate
- Mirtazapine moderate
- Paroxetine moderate
- Trazodone moderate
Meperidine Also Interacts With
- Safinamide major
- Rasagiline moderate
- Tranylcypromine moderate
- Gabapentin minor
- Trazodone minor
Frequently Asked Questions
What SPL severity band is on file for Selegiline + Meperidine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Meperidine has 31 labeled pairs on file vs Selegiline's 9. In the minor band specifically: Selegiline has 3 (also Dopamine, Methylphenidate); Meperidine has 28 (also Gabapentin, Trazodone, Tramadol, Cyclobenzaprine).
What mechanism field is on file for Selegiline and Meperidine?
Combining these drugs can cause a severe and dangerous reaction that affects your muscles, temperature, and brain function.
Meperidine carries more major-labeled pairs than Selegiline
SPL source-record counts only. This page's band is minor · classes on file: Selegiline (Selective MAO-B Inhibitor); Meperidine (Opioid Analgesic).
Meperidine has 1 major-labeled pair vs Selegiline's 0. This page itself is in the minor band, not the major band.
0 major · 6 moderate · 3 minor · 9 total
- Other minor peers for Selegiline
- Dopamine
- Methylphenidate
1 major · 2 moderate · 28 minor · 31 total
- Other minor peers for Meperidine
- Gabapentin
- Trazodone
- Tramadol
- Cyclobenzaprine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.