Selegiline and Levomilnacipran Interaction
Drug interaction information between Selegiline and Levomilnacipran.
Selegiline and Levomilnacipran have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Selegiline and Levomilnacipran. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking these medications together can cause serotonin levels to become dangerously high, leading to a condition called serotonin syndrome.
FDA Label Information
Examples: selegiline, tranylcypromine, isocarboxazid, phenelzine, linezolid, methylene blue Other Serotonergic Drugs Clinical Impact: Concomitant use of FETZIMA with other serotonergic drugs increases the risk of serotonin syndrome.
Selegiline Also Interacts With
- Desvenlafaxine moderate
- Mirtazapine moderate
- Paroxetine moderate
- Trazodone moderate
- Vortioxetine moderate
Levomilnacipran Also Interacts With
- Linezolid moderate
- Phenelzine moderate
- Tranylcypromine moderate
- Buspirone minor
- Aspirin minor
Frequently Asked Questions
What SPL severity band is on file for Selegiline + Levomilnacipran?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Levomilnacipran has 11 labeled pairs on file vs Selegiline's 9. In the moderate band specifically: Selegiline has 6 (also Desvenlafaxine, Mirtazapine, Paroxetine, Trazodone); Levomilnacipran has 4 (also Linezolid, Phenelzine, Tranylcypromine).
What mechanism field is on file for Selegiline and Levomilnacipran?
Taking these medications together can cause serotonin levels to become dangerously high, leading to a condition called serotonin syndrome.
Levomilnacipran's labeled portfolio outnumbers Selegiline
SPL source-record counts only. This page's band is moderate · classes on file: Selegiline (Selective MAO-B Inhibitor); Levomilnacipran (Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)).
0 major · 6 moderate · 3 minor · 9 total
- Other moderate peers for Selegiline
- Desvenlafaxine
- Mirtazapine
- Paroxetine
- Trazodone
0 major · 4 moderate · 7 minor · 11 total
- Other moderate peers for Levomilnacipran
- Linezolid
- Phenelzine
- Tranylcypromine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.