Dopamine and Tetrabenazine Interaction

Drug interaction information between Dopamine and Tetrabenazine.

Dopamine and Tetrabenazine have a documented moderate interaction in FDA labeling.

FDA drug labeling documents a moderate-severity interaction between Dopamine and Tetrabenazine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.

Drug A

Dopamine

Inotropic / Vasopressor

Drug B

Tetrabenazine

VMAT2 Inhibitor

How They Interact

Both drugs affect how dopamine works in the brain. Using them together can cause movement problems or serious nervous system reactions.

FDA Label Information

7.6 Neuroleptic Drugs The risk for Parkinsonism, NMS, and akathisia may be increased by concomitant use of tetrabenazine and dopamine antagonists or antipsychotics (e.g., chlorpromazine, haloperidol, olanzapine, risperidone, thioridazine, ziprasidone) [see Warnings and Precautions ( 5.4 , 5.5 , 5.6 )] .

Frequently Asked Questions

What SPL severity band is on file for Dopamine + Tetrabenazine?

Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.

Which drug in this pair has the larger labeled-interaction portfolio?

Dopamine has 28 labeled pairs on file vs Tetrabenazine's 16. In the moderate band specifically: Dopamine has 5 (also Carbidopa/Levodopa, Deutetrabenazine, Digoxin, Tranylcypromine); Tetrabenazine has 9 (also Olanzapine, Risperidone, Ziprasidone, Haloperidol).

What mechanism field is on file for Dopamine and Tetrabenazine?

Both drugs affect how dopamine works in the brain. Using them together can cause movement problems or serious nervous system reactions.

Tetrabenazine carries more major-labeled pairs than Dopamine

SPL source-record counts only. This page's band is moderate · classes on file: Dopamine (Inotropic / Vasopressor); Tetrabenazine (VMAT2 Inhibitor).

Tetrabenazine has 2 major-labeled pairs vs Dopamine's 0. This page itself is in the moderate band, not the major band.

Dopamine

0 major · 5 moderate · 23 minor · 28 total

Tetrabenazine

2 major · 9 moderate · 5 minor · 16 total

Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.