Selegiline and Paroxetine Interaction
Drug interaction information between Selegiline and Paroxetine.
Selegiline and Paroxetine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Selegiline and Paroxetine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking these two medicines together can cause a dangerous buildup of a brain chemical called serotonin.
FDA Label Information
Examples selegiline, tranylcypromine, isocarboxazid, phenelzine, linezolid, methylene blue Pimozide and Thioridazine Clinical Impact Increased plasma concentrations of pimozide and thioridazine, drugs with a narrow therapeutic index, may increase the risk of QTc prolongation and ventricular arrhythmias.
Selegiline Also Interacts With
- Desvenlafaxine moderate
- Levomilnacipran moderate
- Mirtazapine moderate
- Trazodone moderate
- Vortioxetine moderate
Paroxetine Also Interacts With
- Linezolid major
- Pimozide major
- Thioridazine major
- Phenelzine moderate
- Tranylcypromine moderate
Frequently Asked Questions
What SPL severity band is on file for Selegiline + Paroxetine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Paroxetine has 51 labeled pairs on file vs Selegiline's 9. In the moderate band specifically: Selegiline has 6 (also Desvenlafaxine, Levomilnacipran, Mirtazapine, Trazodone); Paroxetine has 4 (also Phenelzine, Tranylcypromine, Tamsulosin).
What mechanism field is on file for Selegiline and Paroxetine?
Taking these two medicines together can cause a dangerous buildup of a brain chemical called serotonin.
Paroxetine carries more major-labeled pairs than Selegiline
SPL source-record counts only. This page's band is moderate · classes on file: Selegiline (Selective MAO-B Inhibitor); Paroxetine (Selective Serotonin Reuptake Inhibitor (SSRI)).
Paroxetine has 3 major-labeled pairs vs Selegiline's 0. This page itself is in the moderate band, not the major band.
0 major · 6 moderate · 3 minor · 9 total
- Other moderate peers for Selegiline
- Desvenlafaxine
- Levomilnacipran
- Mirtazapine
- Trazodone
3 major · 4 moderate · 44 minor · 51 total
- Other moderate peers for Paroxetine
- Phenelzine
- Tranylcypromine
- Tamsulosin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.