Dopamine and Nortriptyline Interaction
Drug interaction information between Dopamine and Nortriptyline.
Dopamine and Nortriptyline have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Dopamine and Nortriptyline. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Nortriptyline makes the body more reactive to dopamine's effects. This can result in a much stronger effect on your blood pressure than intended.
FDA Label Information
Examples: amitriptyline, desipramine, doxepin, imipramine, nortriptyline.
Dopamine Also Interacts With
- Carbidopa/Levodopa moderate
- Deutetrabenazine moderate
- Digoxin moderate
- Tetrabenazine moderate
- Tranylcypromine moderate
Nortriptyline Also Interacts With
- Bupropion minor
- Carbamazepine minor
- Darunavir minor
- Fluconazole minor
- Norepinephrine minor
Frequently Asked Questions
What SPL severity band is on file for Dopamine + Nortriptyline?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Dopamine has 28 labeled pairs on file vs Nortriptyline's 8. In the minor band specifically: Dopamine has 23 (also Amitriptyline, Doxepin, Linezolid, Imipramine); Nortriptyline has 8 (also Bupropion, Carbamazepine, Darunavir, Fluconazole).
What mechanism field is on file for Dopamine and Nortriptyline?
Nortriptyline makes the body more reactive to dopamine's effects. This can result in a much stronger effect on your blood pressure than intended.
Dopamine's labeled portfolio outnumbers Nortriptyline
SPL source-record counts only. This page's band is minor · classes on file: Dopamine (Inotropic / Vasopressor); Nortriptyline (Tricyclic Antidepressant (TCA)).
0 major · 5 moderate · 23 minor · 28 total
- Other minor peers for Dopamine
- Amitriptyline
- Doxepin
- Linezolid
- Imipramine
0 major · 0 moderate · 8 minor · 8 total
- Other minor peers for Nortriptyline
- Bupropion
- Carbamazepine
- Darunavir
- Fluconazole
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.