Selegiline and Desvenlafaxine Interaction
Drug interaction information between Selegiline and Desvenlafaxine.
Selegiline and Desvenlafaxine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Selegiline and Desvenlafaxine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These medications both raise serotonin levels in your body. Combining them can lead to too much serotonin, which can cause a dangerous reaction.
FDA Label Information
Examples selegiline, tranylcypromine, isocarboxazid, phenelzine, linezolid, methylene blue Other Serotonergic Drugs Clinical Impact Concomitant use of PRISTIQ with other serotonergic drugs increases the risk of serotonin syndrome.
Selegiline Also Interacts With
- Levomilnacipran moderate
- Mirtazapine moderate
- Paroxetine moderate
- Trazodone moderate
- Vortioxetine moderate
Desvenlafaxine Also Interacts With
- Aspirin moderate
- Linezolid moderate
- Phenelzine moderate
- Tranylcypromine moderate
- Warfarin moderate
Frequently Asked Questions
What SPL severity band is on file for Selegiline + Desvenlafaxine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Desvenlafaxine has 19 labeled pairs on file vs Selegiline's 9. In the moderate band specifically: Selegiline has 6 (also Levomilnacipran, Mirtazapine, Paroxetine, Trazodone); Desvenlafaxine has 6 (also Aspirin, Linezolid, Phenelzine, Tranylcypromine).
What mechanism field is on file for Selegiline and Desvenlafaxine?
These medications both raise serotonin levels in your body. Combining them can lead to too much serotonin, which can cause a dangerous reaction.
Desvenlafaxine's labeled portfolio outnumbers Selegiline
SPL source-record counts only. This page's band is moderate · classes on file: Selegiline (Selective MAO-B Inhibitor); Desvenlafaxine (Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)).
0 major · 6 moderate · 3 minor · 9 total
- Other moderate peers for Selegiline
- Levomilnacipran
- Mirtazapine
- Paroxetine
- Trazodone
0 major · 6 moderate · 13 minor · 19 total
- Other moderate peers for Desvenlafaxine
- Aspirin
- Linezolid
- Phenelzine
- Tranylcypromine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.