Dopamine and Digoxin Interaction
Drug interaction information between Dopamine and Digoxin.
Dopamine and Digoxin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Dopamine and Digoxin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These drugs both affect the heart's rhythm and how strongly it beats. Combining them can make the heart beat in an irregular or dangerous way.
FDA Label Information
Sympathomimetics Epinephrine Norepinephrine Dopamine Can increase the risk of cardiac arrhythmias Neuromuscular Blocking Agents Succinylcholine May cause sudden extrusion of potassium from muscle cells causing arrhythmias in patients taking digoxin.
Dopamine Also Interacts With
- Carbidopa/Levodopa moderate
- Deutetrabenazine moderate
- Tetrabenazine moderate
- Tranylcypromine moderate
- Amitriptyline minor
Digoxin Also Interacts With
- Nicardipine major
- Posaconazole major
- Sotalol moderate
- Dofetilide moderate
- Ivabradine moderate
Frequently Asked Questions
What SPL severity band is on file for Dopamine + Digoxin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Digoxin has 120 labeled pairs on file vs Dopamine's 28. In the moderate band specifically: Dopamine has 5 (also Carbidopa/Levodopa, Deutetrabenazine, Tetrabenazine, Tranylcypromine); Digoxin has 13 (also Sotalol, Dofetilide, Ivabradine, Epinephrine).
What mechanism field is on file for Dopamine and Digoxin?
These drugs both affect the heart's rhythm and how strongly it beats. Combining them can make the heart beat in an irregular or dangerous way.
Digoxin carries more major-labeled pairs than Dopamine
SPL source-record counts only. This page's band is moderate · classes on file: Dopamine (Inotropic / Vasopressor); Digoxin (Cardiac Glycoside).
Digoxin has 2 major-labeled pairs vs Dopamine's 0. This page itself is in the moderate band, not the major band.
0 major · 5 moderate · 23 minor · 28 total
- Other moderate peers for Dopamine
- Carbidopa/Levodopa
- Deutetrabenazine
- Tetrabenazine
- Tranylcypromine
2 major · 13 moderate · 105 minor · 120 total
- Other moderate peers for Digoxin
- Sotalol
- Dofetilide
- Ivabradine
- Epinephrine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.