Selegiline and Methylphenidate Interaction
Drug interaction information between Selegiline and Methylphenidate.
Selegiline and Methylphenidate have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Selegiline and Methylphenidate. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Methylphenidate can raise blood pressure, which makes drugs used to lower blood pressure work less effectively.
FDA Label Information
Examples selegiline, tranylcypromine, isocarboxazid, phenelzine, linezolid, methylene blue Antihypertensive Drugs Clinical Impact Methylphenidate hydrochloride extended-release capsules may decrease the effectiveness of drugs used to treat hypertension [see Warnings and Precautions ( 5.3 )] .
Selegiline Also Interacts With
- Desvenlafaxine moderate
- Levomilnacipran moderate
- Mirtazapine moderate
- Paroxetine moderate
- Trazodone moderate
Methylphenidate Also Interacts With
- Safinamide major
- Dexmethylphenidate moderate
- Risperidone moderate
- Linezolid minor
- Phenelzine minor
Frequently Asked Questions
What SPL severity band is on file for Selegiline + Methylphenidate?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Methylphenidate has 11 labeled pairs on file vs Selegiline's 9. In the minor band specifically: Selegiline has 3 (also Meperidine, Dopamine); Methylphenidate has 8 (also Linezolid, Phenelzine, Tranylcypromine, Atomoxetine).
What mechanism field is on file for Selegiline and Methylphenidate?
Methylphenidate can raise blood pressure, which makes drugs used to lower blood pressure work less effectively.
Methylphenidate carries more major-labeled pairs than Selegiline
SPL source-record counts only. This page's band is minor · classes on file: Selegiline (Selective MAO-B Inhibitor); Methylphenidate (CNS Stimulant).
Methylphenidate has 1 major-labeled pair vs Selegiline's 0. This page itself is in the minor band, not the major band.
0 major · 6 moderate · 3 minor · 9 total
- Other minor peers for Selegiline
- Meperidine
- Dopamine
1 major · 2 moderate · 8 minor · 11 total
- Other minor peers for Methylphenidate
- Linezolid
- Phenelzine
- Tranylcypromine
- Atomoxetine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.