Rosuvastatin and Darunavir Interaction
Drug interaction information between Rosuvastatin and Darunavir.
Rosuvastatin and Darunavir have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Rosuvastatin and Darunavir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Darunavir increases the levels of rosuvastatin in your blood, which can raise the risk of muscle damage.
FDA Label Information
atorvastatin, pravastatin, rosuvastatin ↑ HMG-CoA reductase inhibitors Co-administration of darunavir/ritonavir with HMG-CoA reductase inhibitors may lead to adverse events such as myopathy. Titrate atorvastatin, pravastatin or rosuvastatin dose carefully and use the lowest necessary dose while monitoring for adverse events.
Rosuvastatin Also Interacts With
- Sofosbuvir/Velpatasvir major
- Glecaprevir/Pibrentasvir major
- Febuxostat major
- Cyclosporine moderate
- Ledipasvir/Sofosbuvir moderate
Darunavir Also Interacts With
- Lovastatin major
- Sildenafil major
- Lurasidone major
- Pimozide major
- Midazolam major
Frequently Asked Questions
What SPL severity band is on file for Rosuvastatin + Darunavir?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Darunavir has 101 labeled pairs on file vs Rosuvastatin's 21. In the minor band specifically: Rosuvastatin has 10 (also Fenofibrate, Warfarin, Brexpiprazole, Estradiol); Darunavir has 70 (also Amlodipine, Metoprolol, Sertraline, Trazodone).
What mechanism field is on file for Rosuvastatin and Darunavir?
Darunavir increases the levels of rosuvastatin in your blood, which can raise the risk of muscle damage.
Darunavir carries more major-labeled pairs than Rosuvastatin
SPL source-record counts only. This page's band is minor · classes on file: Rosuvastatin (HMG-CoA Reductase Inhibitor (Statin)); Darunavir (HIV Protease Inhibitor).
Darunavir has 15 major-labeled pairs vs Rosuvastatin's 3. This page itself is in the minor band, not the major band.
3 major · 8 moderate · 10 minor · 21 total
- Other minor peers for Rosuvastatin
- Fenofibrate
- Warfarin
- Brexpiprazole
- Estradiol
15 major · 16 moderate · 70 minor · 101 total
- Other minor peers for Darunavir
- Amlodipine
- Metoprolol
- Sertraline
- Trazodone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.