Rosuvastatin and Warfarin Interaction
Drug interaction information between Rosuvastatin and Warfarin.
Rosuvastatin and Warfarin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Rosuvastatin and Warfarin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Rosuvastatin can increase the blood-thinning effects of warfarin. This makes the blood take longer to clot, which can increase the risk of bleeding.
FDA Label Information
( 7.2 ) Warfarin : Obtain INR prior to starting rosuvastatin. Table 7: Rosuvastatin Effects on Other Drugs Warfarin Clinical Impact: Rosuvastatin significantly increased the INR in patients receiving warfarin [see Clinical Pharmacology ( 12.3 )]. Intervention: In patients taking warfarin, obtain an INR before starting rosuvastatin and frequently enough after initiation, dose titration or discontinuation to ensure that no significant alteration in INR occurs.
Rosuvastatin Also Interacts With
- Sofosbuvir/Velpatasvir major
- Glecaprevir/Pibrentasvir major
- Febuxostat major
- Cyclosporine moderate
- Ledipasvir/Sofosbuvir moderate
Warfarin Also Interacts With
- Fluoxetine major
- Tamoxifen major
- Ibuprofen moderate
- Aspirin moderate
- Diclofenac moderate
Frequently Asked Questions
What SPL severity band is on file for Rosuvastatin + Warfarin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Warfarin has 163 labeled pairs on file vs Rosuvastatin's 21. In the minor band specifically: Rosuvastatin has 10 (also Fenofibrate, Brexpiprazole, Darunavir, Estradiol); Warfarin has 133 (also Atorvastatin, Amlodipine, Omeprazole, Famotidine).
What mechanism field is on file for Rosuvastatin and Warfarin?
Rosuvastatin can increase the blood-thinning effects of warfarin. This makes the blood take longer to clot, which can increase the risk of bleeding.
Rosuvastatin carries more major-labeled pairs than Warfarin
SPL source-record counts only. This page's band is minor · classes on file: Rosuvastatin (HMG-CoA Reductase Inhibitor (Statin)); Warfarin (Vitamin K Antagonist (Anticoagulant)).
Rosuvastatin has 3 major-labeled pairs vs Warfarin's 2. This page itself is in the minor band, not the major band.
3 major · 8 moderate · 10 minor · 21 total
- Other minor peers for Rosuvastatin
- Fenofibrate
- Brexpiprazole
- Darunavir
- Estradiol
2 major · 28 moderate · 133 minor · 163 total
- Other minor peers for Warfarin
- Atorvastatin
- Amlodipine
- Omeprazole
- Famotidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.