Rosuvastatin and Febuxostat Interaction
Drug interaction information between Rosuvastatin and Febuxostat.
Rosuvastatin and Febuxostat have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Rosuvastatin and Febuxostat. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Febuxostat slows down how your body gets rid of rosuvastatin, causing the medicine to build up in your blood. This increase can make side effects more likely.
FDA Label Information
Febuxostat Clinical Impact: Febuxostat increased rosuvastatin exposure more than 1.9-fold. Intervention: In patients taking febuxostat, do not exceed a dose of rosuvastatin 20 mg once daily.
Rosuvastatin Also Interacts With
- Sofosbuvir/Velpatasvir major
- Glecaprevir/Pibrentasvir major
- Cyclosporine moderate
- Ledipasvir/Sofosbuvir moderate
- Colchicine moderate
Febuxostat Also Interacts With
- Rosuvastatin/Ezetimibe major
- Theophylline moderate
- Hydrochlorothiazide minor
- Naproxen minor
- Warfarin minor
Frequently Asked Questions
What SPL severity band is on file for Rosuvastatin + Febuxostat?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Rosuvastatin has 21 labeled pairs on file vs Febuxostat's 9. In the major band specifically: Rosuvastatin has 3 (also Sofosbuvir/Velpatasvir, Glecaprevir/Pibrentasvir); Febuxostat has 2 (also Rosuvastatin/Ezetimibe).
What mechanism field is on file for Rosuvastatin and Febuxostat?
Febuxostat slows down how your body gets rid of rosuvastatin, causing the medicine to build up in your blood. This increase can make side effects more likely.
Rosuvastatin carries more major-labeled pairs than Febuxostat
SPL source-record counts only. This page's band is major · classes on file: Rosuvastatin (HMG-CoA Reductase Inhibitor (Statin)); Febuxostat (Xanthine Oxidase Inhibitor).
Rosuvastatin has 3 major-labeled pairs vs Febuxostat's 2.
3 major · 8 moderate · 10 minor · 21 total
- Other major peers for Rosuvastatin
- Sofosbuvir/Velpatasvir
- Glecaprevir/Pibrentasvir
2 major · 1 moderate · 6 minor · 9 total
- Other major peers for Febuxostat
- Rosuvastatin/Ezetimibe
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.