Rosuvastatin and Cyclosporine Interaction
Drug interaction information between Rosuvastatin and Cyclosporine.
Rosuvastatin and Cyclosporine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Rosuvastatin and Cyclosporine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Cyclosporine stops your body from clearing rosuvastatin, leading to much higher levels of the drug in your blood. This increase makes it much more likely that you will experience severe muscle damage.
Rosuvastatin Also Interacts With
- Sofosbuvir/Velpatasvir major
- Glecaprevir/Pibrentasvir major
- Febuxostat major
- Ledipasvir/Sofosbuvir moderate
- Colchicine moderate
Cyclosporine Also Interacts With
- Clarithromycin major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Pitavastatin major
- Simvastatin major
Frequently Asked Questions
What SPL severity band is on file for Rosuvastatin + Cyclosporine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cyclosporine has 89 labeled pairs on file vs Rosuvastatin's 21. In the moderate band specifically: Rosuvastatin has 8 (also Ledipasvir/Sofosbuvir, Colchicine, Gemfibrozil, Niacin); Cyclosporine has 24 (also Aliskiren, Allopurinol, Amiloride, Amlodipine/Valsartan).
What mechanism field is on file for Rosuvastatin and Cyclosporine?
Cyclosporine stops your body from clearing rosuvastatin, leading to much higher levels of the drug in your blood. This increase makes it much more likely that you will experience severe muscle damage.
Cyclosporine carries more major-labeled pairs than Rosuvastatin
SPL source-record counts only. This page's band is moderate · classes on file: Rosuvastatin (HMG-CoA Reductase Inhibitor (Statin)); Cyclosporine (Calcineurin Inhibitor (Immunosuppressant)).
Cyclosporine has 5 major-labeled pairs vs Rosuvastatin's 3. This page itself is in the moderate band, not the major band.
3 major · 8 moderate · 10 minor · 21 total
- Other moderate peers for Rosuvastatin
- Ledipasvir/Sofosbuvir
- Colchicine
- Gemfibrozil
- Niacin
5 major · 24 moderate · 60 minor · 89 total
- Other moderate peers for Cyclosporine
- Aliskiren
- Allopurinol
- Amiloride
- Amlodipine/Valsartan
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.