Darunavir and Trazodone Interaction
Drug interaction information between Darunavir and Trazodone.
Darunavir and Trazodone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Darunavir and Trazodone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Darunavir causes trazodone levels to increase in the body, which can lead to more side effects like dizziness or fainting.
FDA Label Information
Tricyclic Antidepressants (TCAs): amitriptyline, desipramine, imipramine, nortriptyline ↑ amitriptyline ↑ desipramine ↑ imipramine ↑ nortriptyline Use a lower dose of the tricyclic antidepressants and trazodone due to potential increased adverse events such as nausea, dizziness, hypotension and syncope. Other: trazodone ↑ trazodone Antifungals: itraconazole, isavuconazole, ketoconazole, posaconazole ↑ darunavir ↑ itraconazole ↑ isavuconazole ↑ ketoconazole ↔ posaconazole Monitor for increased darunavir/ritonavir and/or antifungal adverse events with concomitant use of these antifungals.
Darunavir Also Interacts With
- Lovastatin major
- Sildenafil major
- Lurasidone major
- Pimozide major
- Midazolam major
Trazodone Also Interacts With
- Linezolid major
- Aspirin moderate
- Phenelzine moderate
- Tranylcypromine moderate
- Selegiline moderate
Frequently Asked Questions
What SPL severity band is on file for Darunavir + Trazodone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Darunavir has 101 labeled pairs on file vs Trazodone's 40. In the minor band specifically: Darunavir has 70 (also Amlodipine, Metoprolol, Sertraline, Rosuvastatin); Trazodone has 35 (also Tramadol, Buspirone, Clopidogrel, Rivaroxaban).
What mechanism field is on file for Darunavir and Trazodone?
Darunavir causes trazodone levels to increase in the body, which can lead to more side effects like dizziness or fainting.
Darunavir carries more major-labeled pairs than Trazodone
SPL source-record counts only. This page's band is minor · classes on file: Darunavir (HIV Protease Inhibitor); Trazodone (Serotonin Antagonist and Reuptake Inhibitor (SARI)).
Darunavir has 15 major-labeled pairs vs Trazodone's 1. This page itself is in the minor band, not the major band.
15 major · 16 moderate · 70 minor · 101 total
- Other minor peers for Darunavir
- Amlodipine
- Metoprolol
- Sertraline
- Rosuvastatin
1 major · 4 moderate · 35 minor · 40 total
- Other minor peers for Trazodone
- Tramadol
- Buspirone
- Clopidogrel
- Rivaroxaban
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.